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USAHS Pharmacology Final Exam – Questions & Answers
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USAHS Pharmacology Final Exam – Questions & Answers
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USAHS Pharmacology Final Exam – Questions &Answers
What is the original NSAID? ✔️Ans - Asprin
What are the four properties of NSAIDs ✔️Ans - -Decrease
Inflammation
-Decrease elevated body temp assoc. w/ fever
-Decrease blood clotting by inhibiting platelet aggragation
(anticoagulation)
-Relieve mild-moderate pain (analgesia)
Antipyresis ✔️Ans - reducing an elevated body temperature
What do NSAIDs interphere with? ✔️Ans - With biosynthesis of
prostaglandins
What are prostaglandins? ✔️Ans - Lipid like compounds that are
biologically active ecosanoids and include thombroxanes and leukotrienes
Ecosanoids ✔️Ans - are diverse lipids chiefly derived from 20-carbon
fatty acid (arachidonic acid) found on all cell membranes.
How do Ecosanoids influence health? ✔️Ans - Cardiovascular,
respiratory, GI, Renal, nervous, and reproduction
Problems with excessive prostaglandin sythnesis (8): ✔️Ans -
Inflammation
Fever
Pain
Dysmenorrhea
Thrombus
Neoplasm
, HTN
Colon Cancer
dysmenorrhea ✔️Ans - painful menstruation
arachnodonic acid will make ✔️Ans - cyclo-oxygenase
Cyclogenase will make ✔️Ans - prostalandins unless NSAIDs block that
MOA of NSAID action (normal cell) ✔️Ans - Normal cell ->
Physiologic stimulus (i.e excessive GI acid) -->
COX-1 "constitutive" -->
House keeping cells
Cox-1 ✔️Ans - "house keeping"
THE BENEFICIAL ONE
MOA of NSAID action (injured cell) ✔️Ans - Injured Cell --->
Inflammatory response --->
COX-2 "Injury induced" --->
PGI2 and PGE2 ---->
INFLAMMATION
COX-2 ✔️Ans - triggers inflammation and pain
Emergency enzyme
COX that suppresses pain ✔️Ans - COX-2
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