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UNE Biochemistry Final 100-215 Questions And Answers
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UNE Biochemistry Final 100-215 Questions AndAnswers
If unregulated, which of the following pairs of enzymes would represent a
futile cycle? Correct Ans - Fructose-1,6-bisphosphatase and
phosphofructokinase 1
Ethanol metabolism Correct Ans - Increases the ratio of
NADH/NAD+
The first step in ethanol metabolism is in the cytosol and generates which
of the following products? Correct Ans - Acetaldehyde
Acetate generated from ethanol metabolism can be directly converted to
_____________________ which can be oxidized in the TCA cycle. Correct Ans
- Acetyl CoA
Increase in ethanol consumption leads to an increase in the ratio of
NADH/NAD+. This promotes the conversion of pyruvate to which fo the
following compounds? Correct Ans - Lactate
The oxidation of ethanol increases the ratio of NADH/ NAD in both the
mitochondria and the cytosol. This leads to the inhibition of which of the
following enzymes in the TCA cycle? Correct Ans - Isocitrate
dehydrogenase
Several friends went out Saturday evening to celebrate an exam. They
skipped dinner and decided to head straight to the bar. The next morning
one of the individuals was found laying unconscious at the bottom of the
stairs. He was rushed to the emergency department and blood glucose
levels of 30mg/ dL (normal range 100-120mg/ dL).
At the time of presentation, which of the following would be consistent
with this individuals signs and symptoms (when compared to a normal
individual)? Correct Ans - Increase lactate levels
Which of the following is the primary metabolic fate of acetate generated
from ethanol metabolism? Correct Ans - It is converted to acetyl
CoA by peripheral tissues
,Both gluconeogenesis and fatty acid beta oxidation are required for
homeostasis in the fasted state. Which of the following statements is false
with regards to how these pathways interact? Correct Ans - Acetyl
CoA is a substrate required for gluconeogenesis
Which of the following hormones initiates skeletal muscle catabolism to
provide substrate for gluconeogenesis? Correct Ans - Cortisol
In a fasted individual, excessive alcohol consumption will contribute to all
of the following except Correct Ans - Increased chylomicron
secretion
Ethanol metabolism increases the ratio of NADH/NAD+. This leads to all of
the following metabolic consequences except Correct Ans -
Inhibition of lipolysis
Which of the following is the primary factor leading to the inhibition of
gluconeogenesis when excessive alcohol is consumed? Correct Ans -
Increase in the ratio of NADH/NAD+
All of the following are potential substrates for gluconeogenesis except
Correct Ans - Acetyl CoA
The oxidation of ethanol initially takes place in the ____________ and the
enzyme alcohol dehydrogenase converts ethanol to __________________.
Correct Ans - Cytosol; Acetaldehyde
During fatty acid synthesis, after the initial step involving acetyl CoA, the
fatty acid chain is elongated by the addition of which of the following
compounds? Correct Ans - Malonyl CoA
Excessive alcohol consumption can lead to the presentation of
hypoglycemia. This is primarily caused by which of the following?
Correct Ans - A decrease in substrates required for gluconeogenesis
What is the primary fuel oxidized in the liver (to generate ATP) in the
fasted state? Correct Ans - Free fatty acids
, The elevated levels of NADH/NAD generated by alcohol metabolism inhibit
all of the following except Correct Ans - Pyruvate dehydrogenase
kinase
Shortly after meal high in fat you would expect an elevation of which of the
follow lipoproteins in circulation? Correct Ans - Chylomicrons
Under fasting conditions, acetyl CoA carboxylase will be inhibited by an
increase in which of the following compounds? Correct Ans -
Palmitoyl CoA
Which of the following is consistent with an insulin/glucagon ratio of >1?
Correct Ans - glycogen phosphorylase, dephosphorylated, inacitve
Pyruvate carboxylase is allosterically by which of the following
compounds? Correct Ans - Acetyl CoA
Which lipoprotien is responsible for the process of reverse cholesterol
transport (the movement of cholesterol from the peripheral tissues back to
the liver)? Correct Ans - HDL
Which of the following enzymes is responsible for the conversion of
ethanol to acetaldehyde in the cytosol? Correct Ans - Alcohol
dehydrogenase
Gluconeogenesis generates glucose 6-phosphate. Which of the following is
the primary fate of this compound generated by this process? Correct
Ans - Dephosphorylation and release into circulation
Which of the following apoproteins is present on an LDL particle and
required for uptake by peripheral tissues? Correct Ans - ApoB100
Which enzyme is responsible for transferring triacylglycerol from VLDL to
HDL in exchange for cholesterol? Correct Ans - CEPT (cholesterol
ester transferase protein)
Which of the following is the full complement of apoproteins present on
VLDLs? Correct Ans - ApoB100, ApoCII, ApoE
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