Exam (elaborations)
OCN Drugs Questions with solutions 2023
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Exam of 13 pages for the course OCN at OCN (OCN Drugs)
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OCN DrugsBiotherapy - answer the treatment of disease using substances obtained or derived
from living organisms.
Tyrosine kinase inhibitors: MOA, examples, - answer MOA: TKIs bind to the tyrosine
kinase in EGFR, inactivating it or limiting its activity.
-tinib
Erlotinib
Ponatinib
Imatinib
Dasatinib
Ibrutinib
Kinase inhibitors - answer MOA: Kinase inhibitors target the RAF/RAS/MET pathway
-nib
Sorafenib,
Dabrafenib
Trametinib
Vemurafenib
PI3K inhibitors - answer MOA: The PI3K pathway regulates cell survival and
proliferation. When abnormal activation of this pathway occurs, scientists identified
survival and proliferation of tumor cells in many cancers.
-lisib
Idelalisib
Hedgehog - answer MOA:The Hedgehog Pathway is known to most by its role in
normal embryonic development (e.g., brain and spinal cord development). In adults, the
sonic hedgehog pathway controls cell division of adult stem cells and cell differentiation.
-gib
Sonidegib
Vismodegib
, Targeted therapy side effects - answer -sensitivity
-skin rash
-cardiovascular
-bleeding/clotting
-impaired wound healing
Hormone therapy MOA - answer Block the hormones from acting,
Prevent the body from producing the hormone,
Eliminate the hormone receptors on the cell surface or change their shape
Antiestrogens - answer hormone therapies, tamoxifen, fulvestrant
Aromatase inhibitors - answer hormone therapies, anastrozole, exemestane
Antiandrogens - answer hormone therapies, bicalutamide, flutamide
Luteinizing hormone releasing hormone agonist - answer hormone therapies,
goserelin, leuprolide
G0 phase - answer A nondividing state in which a cell has left the cell cycle.
G1 phase - answer cell starts making more proteins and growing larger
S phase - answer the chromosomes containing the genetic code (DNA) are copied,
G2 phase - answer the cell checks the DNA and gets ready to start splitting into two
cells
M phase - answer mitosis, cell splits into two new cells
Alkylating agents MOA - answer interfere with DNA replication, RNA transcription,
and nucleic acid function. Cell cycle nonspecific
Alkylating Agents types - answer Non-platins and platinoids
Alkylating Agents Side Effects - answer bone marrow damage, can lead to Acute
leukemia, infertility
Non-platins - answer Nitrogen mustards: Mechlorethamine, chlorambucil,
cyclophosphomide, ifosfamide, melphalan
Nitrosoureas: Streptozocin, carmustin, lomustine
Alkyl sulfonates: Busulfan
Triazines: Dacarbazine, temozolomide
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