تجميعه الكيزز و الاساله كااااااملة باذن الله تعالي في 32 صفحه فقط
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analgesic and anti-inflammatory drug? NSAID has more enterogenic effect? ( Piroxicam )
2. MOA of anti-inflammatory ? ( Decrease prostaglandin )
3. Most likely drug causes Peptic ulcer? Piroxicam Or Ketorolac Or Indomethacin
4. Man take overdose from drug then take the antidote but still no effec...
صفحه فقط32 تجميعه الكيزز و االساله كااااااملة باذن هللا تعالي في
1. Long action analgesic and anti-inflammatory drug? NSAID has more enterogenic effect? ( Piroxicam )
2. MOA of anti-inflammatory ? ( Decrease prostaglandin )
3. Most likely drug causes Peptic ulcer? Piroxicam Or Ketorolac Or Indomethacin
4. Man take overdose from drug then take the antidote but still no effect, why? ( antidote dose was small )
5. Biological substance can be stored at … C ? ( 2–8C )
6. What pharmacist should do when wrong medication prescribed from Dr? ( Inform prescriber doctor )
7. What should do with elderly man with hypertension? ( start with small initial dose then increase )
8. What should do with girl has seizure and tremor رعشهwhen use Oxcarbazepine "anti-convulsant" ?
( shift to Topiramate ) "Topamax"
9. TTT of trigeminal neuralgia ? ( Carbamazepine ) "Tegretol"
10.Child taking Oxcarbazepine suffers from rash and redness, ? shirf to Topiramate Or Ethosuximide
N.B ; this shifting is due to the child because this S.E is normal side effect ,, in case of adult ; keep using Oxcarbazepine
11.Medication is used to treat absence seizures ? ( Ethosuximide )
12.Pt suffered before from migraine attack with aura, he needs drug as prophylaxis? ( Topiramate 25 mg twice )
13.Middle age man has HbA1c=9 and he takes Glipizide + Lisinopril + Pioglitazone عالج سكرDr add ? ( insulin )
14.Example of drug - disease interaction? ( Pioglitazone & heart failure ) ( Celecoxib & Cardiac toxicity )
15.Woman wants to be pregnant, she takes metformin and pioglitazone, she has history of hypoglycemic and prefers oral therapy,
best TTT? ( Stop pioglitazone and titrate metformin ) N.B ; side effect of pioglitazone is Hypoglycemic
16.Normal range of HbA1c is ; non-diabetic 4 – 5.6
17.Bioavailability of Diclofenac injection in muscle ; 100%
18.Bioavailability refers to extent and rate at which the active moiety enters…..? ( systemic circulation ) "site of action"
19.Heparin & Warfarin are contra-indicated with? ( Aspirin & Diclofenac & ibuprofen )
20.Heparin or Warfarin if I added to Aspirin will lead to? ( Bleeding )
21.Interaction between warfarin and ibuprofen cause risk of bleeding, why? ( warfarin will be replaced by ibuprofen )
22.Warfarin oral anti-coagulant is determined or calculated by? ( INR international normalized ratio )
23.Heparin injection anti-coagulant is determined by? ( APTT activated partial thromboplastin time )
24.Heparin and warfarin were prescribed for patient, how long he will take heparin and how much INR ?
( take heparin for 2 days with warfarin then stop heparin , warfarin biological T1/2 is 48 hours
25.Best counseling point for patients taking warfarin? ( Vit K consistent )
26.Anti-dote of warfarin? Vitamin K other name Phytomenadion , phylloquinone K1 , menaquinone K2 , menadione K3
27.Anti-dote of Heparin? Protamine sulfate
28.Anti-dote of Paracetamol? N-Acetyl Cysteine Anti-dote of iron? Deferoxamine
29.Drug acts on non-receptor mechanism? Drug is used to remove excess iron by binding to free iron? Deferoxamine
30.Which decreases warfarin actions? Multivitamins
31.Which drug cause nasal bone hypoplasia? Warfarin
32.Drug that increases action of Warfarin? None of the above
33.Why should warfarin be stopped if woman want to be pregnant? Cranial facial abnormality
34.Warfarin affects ? the vitamin K dependent clotting factors II , VII , IX , X
Heparin increase ? increases the action of anti-thrombin on thrombin and factor Xa
35.Decrease or increase dose to the patient by technician is? Omission error اي خطأ في الجرعهOr ( improper dose error )
36.Types of error in Pharmacy? dispensing error
37.Nurse gives patient dose 2 hours later, what is the type of error? wrong time error , administration error
38.Example of error of deteriorating drug? giving expired drug , storing drug out Refrigerator
39.Most occurring error in prescription? wrong drug order
40.Most error that may occur when patient is transferred from one unit of facility to another? missing drug he was taking
41.Dr prescribes Chlorpheniramine for driver but the pharmacist discover problem? the error occur and drug won't reach Pt
مش محتاج من اي حد غير دعوة حلوة وربنا يوفق الجميع اللهم امين
, PH / Amir Ahmed This file is free NOT FORE SALE
42.Barbiturates are Sedatives, Analgesics, and anti-convulsant Ex / ……barbital
ultra short barbiturates are used mainly? Anesthesia Ex / methohexital - thiopental - thiamylal
43.Side effect of Barbiturates in elderly patient? Agitation Or Excitement confusion لو االتنين مش موجودين
44.Drug with slow metabolism? Phenobarbital ; that is short acting barbiturate
45.Anti-fungal Amphotericin B is used for what infection? Systemic & Subcutaneous
46.Acyclovir is used for? Herpes simplex virus
47.MOA of anti-emetic Metoclopramide ?
dopamine D2 antagonist "dopamine blocker" , agonist on serotonin 5-HT4 receptor , weak inhibition of 5-HT3 receptors
48.Metoclopramide action on which area? Chemo trigger zone
49.Which drug increase milk production by increase prolactin level? Metoclopramide , Domperidone
50.Which drug decrease milk supply? Ergotamine , Estrogen , bromoceptrin
51.TTT of nausea and vomiting in Breastfeeding? Domperidone "anti-emetic without CNS effect" , Metoclopramide
52.Duration of using Domperidone? 3 – 5 Days not be used for more than 7 days اقصي مده اسبوع
53.MOA of domperidone? Dopamine antagonist & can't cross BBB
54.MOA of Doxazosin ? inhibits postsynaptic alpha 1 adrenergic receptor
55.Duration of Esomeprazole in gastroesophagial disease? up to 24 hours
56.Esomeprazole for esophageal injury? 30 days
57.Which committee rules out a drug from the hospital? Therapeutic evaluation committee
58.Non formulary drug order reviewed by? = Management of the drug? Pharmacy & therapeutic committee
59.Formula of drug can be adjusted by? = Removing a drug from formulary? Pharmacy & therapeutic committee
60.MOA of statin? Decrease cholesterol by inhibiting HMG-CoA reductase
61.Which drug with statins can cause myopathy ?مرض بالعضالت Gemfibrozil
N.B ; Fibrates as Gemfibrozil is used for hyperlipidemia and act on triglycerides
62.Most likely to interact with statins? Daptomycin مضاد حيوي
63.Drug exaggerated blood glucose level? Statin or Hydrochlorothiazide
64.Drug can cause short onset of diabetes? Drug decrease synthesis of cholesterol in liver? Simvastatin
65.Diabetic patient needs drug for hyper-triglyceridemia? Statin as atorvastatin
66.Patient needs drug for hyper-triglyceridemia? Gemfibrozil
67.Maximum dose of simvastatin in geriatric ? = dose of simvastatin in hypercholestremia ? 40 mg دي اقصي جرغه الي ستاتين
68.Old man is on Verapamil "Anti-HTN" , but he will start to take simvastatin with dose? 10 mg/day
69.Which is contra-indicted with statin? Ketoconazole - Gemfibrozil
70.BUN , Creatinine , Potassium , Sodium is high so patient should stop? ( Gemfibrozil ) or ( Metformin ) علي حسب االختيارات
71.To determine severity of myopathy caused by Statins? Serum creatinine kinase بيحلل اي تعب بالعضالت
72.TTT of H.Pylori? Clarithromycin + Amoxicillin + PPI as omeprazole or pantoprazole
73.20 mg of omeprazole equal to what of pantoprazole or ranitidine in H.Pylori ttt? 40 mg pantoprazole
74.Sensitivity test of Penicillin done after? 30 days or more or more than 20 days
75.Penicillin sensitivity test for intradermal stage which is must? Skin scratch test
76.Penicillin allergy test is completed in about? 1 Hour
77.Via scratch and intradermal test in Penicillin skin test should wait for? 15 – 20 minutes
78.Patient with pneumonia went to hospital to get vaccine, which should give? both Pneumonia and Influenza only
79.Pregnant women suffer from upper respiratory disease took ceftriaxone IV, Which vaccines hospital should give her? //
80.Patient suffers from lung obstruction, which vaccine should he take? //
81.Rhabdomyolysis can be detected by? Creatine kinase level , serum Ca , myoglobin K , urine analysis
82.Which anti-psychotic patient has involuntary movements, gain weight, can't sleep , isolated from people must take?
Clozapine then Haloperidol
83.Pt suffers from psychosis, he takes medications, he developed involuntary movements, what drug he takes? Haloperidol
84.Clozapine cause? Propylthiouracil cause? Agranulocytosis ; lower white blood cells
85.Pt on Clozapine, what should be checked during ttt RBCs? Neutrophils
86.What will happen if we break down sustained release drug instead of using it as tablet? Toxicity
87.What is the toxic when breakup sustained release drug? multi-dose toxicity
88.Laxative is contra-indicated in pregnancy ? Castor oil
مش محتاج من اي حد غير دعوة حلوة وربنا يوفق الجميع اللهم امين
, PH / Amir Ahmed This file is free NOT FORE SALE
89.MOA of Bisacodyl is? Stimulation of enteric nerves to cause colonic contractions
90.What is the lowest potency laxative? Bisacodyl
91.What has the lowest onset of action in laxatives? Psyllium
92.Newborn baby is prescribed for him Morphine, what is the best route of administration? IV
93.Neonate suffers from cardio coagulopathy, so Vit K should be administered through? IM
94.Who is the reasonable for determining the best dosage form? Pharmacist/Clinical pharmacist وليس الطبيب
95.Patient entered hospital suffering from cramps, gave him Diazepam "Skeletal muscle relaxant" but there is no effect because
this patient is addicted to kind of? Opioid
96.Pt came to emergency with respiratory depression? Opioid
97.Uses of opioids? analgesic - antidiarrheal - antitussive - aids to anesthesia Not anti-inflammatory
98.TCA ; Amitriptyline - Amoxapine - Desipramine - Doxepin - Imipramine - Nortriptyline - Protriptyline - Trimipramine
MOA ; inhibit the reuptake of the biogenic amines at synaptic , mostly norepinephrine (NE), as well as serotonin (5HT)
99.Tetracyclic antidepressant (TeCA) ? Maprotiline - Mirtazapine - Amoxapine
100. Patient with severe HTN & tremors and he is addicted, what is best anti-depressant? Amitriptyline
101. Pt with depression took Amitriptine, but he felt depression after 2 weeks so Dr should? shift
102. Which drug has more effect as skeletal muscle relaxant? Doxacurarine
103. Drug undergo phase 1 metabolism? Drug is used in ER stress response? Drug change mental statues? Diazepam
104. Which drug has fastest action diazepam or Lorazepam ? Lorazepam ; hypnotic at dose 4 mg
105. MOA of Diazepam? ( inhibit glutamate secretion ) , modulate postsynaptic effects of GABA-A transmission
MOA of benzodiazepines? enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) = GABA agonist
106. Effects of benzodiazepine in Breastfeeding ? Enter breast milk & not recommended
107. Benzodiazepine ? anti-convulsion & anxiolytic االهم
108. Drug cause sedation for fetus in 3rd trimester? Benzodiazepine
109. What is the anti-dote of benzodiazepine? Antidote of Zolpidem ? Flumazenil
110. Benzodiazepines include? ( Chlordiazepoxide , alprazolam , estazolam , clorazepate , diazepam , ….zepam )
111. Patient has benzodiazepine toxicity, Flumazenil is given but patient did not respond, Why ???
Because antidote was given to patient after 4 hours or small amount of antidote
112. Nicotinic drugs are labeled in Hospital pharmacy? N
113. In large amount of parental medication, we use? Sterile water for Injection
114. In pediatric analgesic for tooth growth pain, what is contra-indicated and affect on the brain? Aspirin
115. Teething gel for children contain? Anti-septic مفيش مخدر
116. Drug must keep in dark box, used for pain of toothache, dangerous effect to infant as seizure and toxicity? Clove oil
117. Man with BMI 85% of his age, so he is? Very obese مشhighly
118. Child with BMI 85% of his age, so he is? Obese
119. Child with BMI 85% of his age has muscle and skin thickness, so he need test? Body fat
120. Five years old child with BMI 80% of his age, so he is? Normal range
121. Antidote of Narcotics as Tramadol is? Antidote for Pt with drowsiness ,dry mouth, pupil constriction? Naloxone
122. Which decrease gastric empty rate? Atropine & hypothyroidism N.B ; Atropine is muscarinic antagonist
123. Antidote of Atropine ? Physostigmine " Physostigmine is used ttt of Glaucoma "
Side effects of Atropine ? urine retention
124. TTT of open angle glaucoma ? Pilocarpine or Brimonidine اثناء الحمل
125. Drop for ttt of open angel glaucoma, one drop per day ….? at night
126. Selective beta 1 blocker is used in TTT of glaucoma? Betaxolol N.B ; Timolol is non-selective Beta blocker
127. Dose of naloxone in Pediatric? ( 1-2 mg ) but now 0.1 mg/kg 5 او عمرهم اقل من02 للي وزنهم اقل من, 2mg لالكبر
128. In elderly, what is Physiological effect of drug distribution? increase lipid sol & decrease water sol drugs
129. Drug will be more absorbed in presence of H2 blocker as Ranitidine "increase dissolution rate" ? Naproxen
130. Pregnant woman take Naproxen "NSAID", what harm could to baby? Uncontrolled bleeding
131. Pregnancy with otitis media? Azithromycin
132. TTT of otitis media in children? high dose of Amoxicillin or Azithromycin
133. TTT for polyneuritis in pregnancy? amoxicillin/clavulanate 500/125 mg orally twice daily for 3 – 7 days
134. Take Mycophenolate "Cellcept" بيقلل المناعهshe want to be pregnant? stop Myco before 6 weeks of trying to be pregnant
مش محتاج من اي حد غير دعوة حلوة وربنا يوفق الجميع اللهم امين
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