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CPHON EXAM WITH QUESTIONS AND ANSWERS
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CPHON EXAM WITH QUESTIONS ANDANSWERS
Examples of Alkylating Agents - ANSWER Carboplatin, Cisplatin, Carmustine, Lomustine,
Cytoxan, Ifosfamide, Melphalan, Temozolomide, Thiotepa
Examples of Antimetabolites (Cell-cycle Specific) - ANSWER MTX, 5-FU, ARA-C, 6-MP, 6-TG
Examples of Plant Detrivatives (Cell-cycle Specific) - ANSWER Etoposide, irinotecan,
vincristine
Examples of Antibiotics for Cancer treatment - ANSWER Dactinomycin, Bleomycin
Examples of Anthracyclines - ANSWER Doxorubicin, Daunorubicin
Misc chemotherapy class examples - ANSWER Peg, procarbazine, decarbazine
If Extravasation, apply cold compresses for every chemo except - ANSWER Vincristine and
Etoposide. Apply warm compress for these chemos
Common late effect of Alkylating Agents - ANSWER Thyroid Abnormalities. Examples:
Cytoxan, Melphalan, Ifos, and Busulfan
Common late effect of anthracyclines - ANSWER Cardiac Toxicity. Examples: Doxo, Dauno,
and Mitoxantrone
Common late effect of vinca alkaloids - ANSWER Peripheral Neuropathy. Examples:
Vincristine, Vinblastine, Etop
Common late effect of heavy metal agents - ANSWER Hearing Deficits. Examples: Cisplatin
and Carboplatin
Common late effect of Hormone Agents - ANSWER Cataracts, Glaucoma, Uveitis:
Prednisone and Dexamethasone
Common Cancers with Late Thyroid Issues - ANSWER Hodgekins, Germ Cell, CNS tumors,
NBL treated with radiolabeled Ab, BMT with TBI
Common Cancers with Late GU Issues - ANSWER NBL, Wilm's, Fanconis
Common Cancers with Late Reproductive Issues - ANSWER Medulloblastoma,
Osteosarcoma, Ewings, and HSCT
,Common Cancers with Secondary Malignancy Risk - ANSWER AML, Sarcomas, Thyroid,
Colorectal, Skin, and CNS Tumor
Common Cancers with Late CNS issues - ANSWER Phil + ALL and T Cell ALL
Chemotherapy for ALL - ANSWER ARA-C, Doxo, Steroids, Mtx, Vcr, Peg, 6mp
Chemotherapy for AML - ANSWER ARA-C, Doxo, Steroids, Etop, 6tg
Chemotherapy for NHL (overall) - ANSWER ARA-C, Doxo, Prednisone, MTX, VCR, Cytoxan,
Etop, Ifos
Chemotherapy for HL - ANSWER Prednisone, MTX, VCR, Cytoxan, Etop, Bleo, Procarb/dac,
Vinblastine
Chemotherapy for Brain Tumors - ANSWER VCR, Cytoxan, Etop, Carbo/cisplatin, Thiotepa,
Carmustine/Lomustine, Temozolomide, Irinotecan
Chemotherapy for NBL - ANSWER VCR, Cytoxan, Etop, Carbo/cisplatin, Thiotepa, Doxo,
Melphalan
Chemotherapy for Wilm's Tumor - ANSWER VCR, Cytoxan, Etop, Doxo, Dactino, Carbo
Chemotherapy for Rhabdo and Ewings - ANSWER VCR, Cytoxan, Etop, Doxo, Dactino, Ifos
Chemotherapy for Osteosarcoma - ANSWER HDMTX, Doxo, Cisplatin, Ifos/Etop
Chemotherapy for Retinoblastoma - ANSWER Carbo, Etop, VCR (CEV)
Late Effect of ARA-C - ANSWER Neurocognitive
Late Effect of MTX - ANSWER Neurocognitive, Hepatic, Bone Loss
Late Effect of VCR - ANSWER Peripheral Neuropathies
Late Effect of Doxorubicin - ANSWER Cardiotoxic, Hepatic, and Secondary Malignancy
Late Effect of 6-MP - ANSWER Hepatic
Late Effect of Steroids - ANSWER Osteopenia/porosis/necrosis, Cataracts
Late Effect of Cytoxan - ANSWER Bladder/Urinary Tract (Include Cancer), Alkylating Agent
Effects (Reproductive, Thyroid, MDS, and 2nd Malignancy)
Alkylating Agent Effects - ANSWER Reproductive, Thyroid, MDS, and 2nd Malignancy
Late Effect of Ifosfamide - ANSWER Renal, Bladder, Urinary Trace (Include Cancer),
, reproductive issues
Late Effect of Etoposide - ANSWER Peripheral Neuropathies, Secondary Malignancy
Late Effect of Dactinomycin - ANSWER Hepatic
Late Effect of Cisplatin and Carboplatin - ANSWER Peripheral Neuropathy, Renal, Ototoxic,
Alkylating Agent Effects
Late Effect of Bleomycin - ANSWER Pulmonary Fibrosis, interstitial Pneum
Late Effect of Carmustine/Lomustine - ANSWER Pulmonary Fibrosis, interstitial Pneum,
Alkylating Agent Effects
Late Effect of Procarbazine - ANSWER Secondary Malignancy
Late Effect of Temozolomide - ANSWER Secondary Malignancy, Reproductive Issues, MDS
Late Effect of Melphalan - ANSWER Reproductive Issues, MDS
Late Effect of Busulfan - ANSWER Cataracts, hypogonadism
Late Effect of Irinotecan - ANSWER Diarrhea (Tx: Immodium. Atropine if early effect)
Phase 1 Trial - ANSWER Determine Maximum tolerated dose
Phase 2 Trial - ANSWER Investigates efficacy of a new agent treating a specific disease
Phase 3 Trial - ANSWER New drug vs. existing treatment
Phase 4 Trial - ANSWER Determines Long-term safety and efficacy
Infant Psychosocial and Cognitive Level - ANSWER Sensorimotor. Trust vs. Mistrust
Toddler Psychosocial and Cognitive Level - ANSWER Preoperational-Preconceptual.
Autonomy vs. Shame and Doubt
Preschooler Psychosocial and Cognitive Level - ANSWER Preoperational-Intuitive.
Initiative vs. Guilt
School-Age Psychosocial and Cognitive Level - ANSWER Concrete Operations. Industry vs.
inferiority
Adolescent Psychosocial and Cognitive Level - ANSWER Formal Operations. Identity vs.
Role Confusion
N-MYC Prognosis for NBL - ANSWER Bad
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