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UNE BIOCHEMISTRY MIDTERM REVIEW QUESTIONS WITH 100% CORRECT ANSWERS
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UNE BIOCHEMISTRY MIDTERM REVIEWQUESTIONS WITH 100% CORRECT
ANSWERS
Under low energy conditions, AMP will bind to phosphofructokinase I and glycogen
phosphorylase at site unique to the active site. This enhances the activity of these enzymes.
This is an example of which of the follow types of enzyme regulation? - answer Allosteric
activation
An example of enzyme activation by cleavage is best illustrated by which of the following? -
answer Activation of chymotrypsinogen to chymotrypsin
Children with cystinosis have growth delay and both renal and ocular issues due to
accumulation of cysteine in cellular lysosomes. The defect involves a specific lysosomal
membrane receptor that facilitates cysteine removal from the cell. An effective therapy has
been administration of a drug with a similar structure to cysteine. This therapy reflects the
general principle that competitive inhibitors typically resemble the structure of which of the
following? - answer Substrates or ligands that bind the active site
The association of DNA and histones can be modified by histone acetylation. A decrease in
histone acetylation will have which of the following impacts on the association of DNA and
histones? - answer Increase DNA: histone association
A 28-year-old male is recently diagnosed with HIV. As part of his treatment he is prescribed
Nevirapine which interferes with retroviral reverse transcriptase enzyme. Using the graph
below, which of the following best describes the impact of this drug on its target? - answer It
reduces the catalytic activity of the enzyme
Which of the following is an example of enzyme regulation through covalent modification? -
answer Phosphorylation of muscle glycogen phosphorylase
, Use the figure below to compare the activities of glucokinase and hexokinase. Based on this
information, which of the following is a true statement? - answer Glucokinase has a higher Km
than hexokinase.
A new enzyme is discovered that increases in activity when it is phosphorylated on an exposed
tyrosine residue. Phosphorylation of this amino acid is classified as which of the following? -
answer Covalent modification
An enzyme is participating in a general acid-base catalysis reaction with an optimal reaction pH
of 6.0. If acid is added to the environment reducing the pH to 3, what is the likely impact to the
rate of reaction? - answer The rate of the reaction is likely to decrease as the pH is out of
optimal catalytic range
If a mutation is made within the active site of an enzyme resulting in a decrease in Km, which of
the following will be true with respect to the enzyme kinetics? - answer The enzyme will require
a lower substrate concentration to reach ½Vmax
In the malate aspartate shuttle, glutamate is converted to _________ in the mitochondria while
aspartate is converted to ___________ in the cytosol. - answer α-ketoglutarate; oxaloacetate
ATP is a high energy molecule that is often hydrolyzed during reactions. The energy within ATP is
stored primarily in which of the following components of the molecule? - answer In the high
energy phosphate bonds
Which of the following would be consistent with an exergonic reaction? - answer ΔG0 would be
negative
The malate-aspartate shuttle is used to move reducing equivalents of cytosolic NADH into the
mitochondria where it can be oxidized. Which of the following compounds is used to move the
reducing equivalents from cytosolic NADH into the mitochondria? - answer Malate
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