BMTCN Study Exam Questions & Answers 2023/2024
Myeloid - ANSWER-erythrocyte, platelets, neutrophil, basophil, eosinophil, monoblast, macrophage, monocyte
lymphoid - ANSWER-pre- B cell, pre-t cell, plasma cell, natural killer cell, t lymphocyte
innate immunity - ANSWER-occurs naturally- phagocytes release inflammatory mediators
acquired immunity - ANSWER-response of either b or t cells to antigens
senescence - ANSWER-loss of cells power to divide and grow
immunosenescence - ANSWER-reduction in size of thymus and function of immune cells
first responders - ANSWER-myeloid
second responders - ANSWER-lymphoid- pathogen specific
syngeneic - ANSWER-identical twin, don't need immunosuppression, con- no graft vs tumor effect
graft vs. tumor effect - ANSWER--promoted by withdrawal of immunosuppressant therapy
-promoted by DLIs
-dec. in absence of acute gvhd
-higher rate of relapse DLI - ANSWER-infusion of lymphocytes from donor given when there is relapsed disease. Attempt to create GVT effect
PBSCT - ANSWER-- 70 %, - faster engraftment, no anesthesia risks, dec. likelihood of contamination by tumor, -higher risk of gvhd, - but better gvt effect- so dosent make sense for SCD
G-CSF - ANSWER-filgrastim. a glycoprotein stimulates the production of stem cells by binding to certain cell surface areas
GM-CSF - ANSWER-sargramostim. lower stem cell yields. and inc adverse events. similar mechanism of action
chemo induced mobilization - ANSWER-chemo causes reduction in production of blood cells thus stimulating hematapoetic recovery. -cyclophosphamide
-paclitaxel
-etoposide
-cytarabine
-improved mobilization
-more rapid engraftment
-reduced risk of tumor cell contamination
chemokine antagonist mobilization - ANSWER-directly induce mobilization by working as antagonist between the chemokine stromal-derived-factor- 1 and receptor CXCR4.
-Plerixafor
-often in combination with GCSF
red bone marrow - ANSWER-produces stem cells that create rbcs, whit bcs, and plts. found in long and flat bones
yellow bone marrow - ANSWER-produce stromal stem cells that produce fat, cartilage and bone. found in long bones
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