Summary- lymphatic system histology, anatomy and pathology
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Course
MED001
Institution
Eastern Mediterranean University
Detailed summary of lymphatic system. This summary includes anatomy of lymphatic organs and nodes, functions of lymphatic system, histology of lymphatic organs and cells and pathology of neoplastic disorders of lymphatic system like Hodgkin’s Lymphoma.
↳
superficial a 10
->
- subcutaneous regions:axillary, pelvic, mediastinal... arise in
lymphoid organs -> mature -> se
layer of skin-> drain to deep contains:
lymphocytes, macrophages... divided into 3:T cells, B
->
cells, NK cells
vessels ↳ serve IT cells
lymphatic as a filtration point for lymph. "B cell: produce antibody and
↳
lymph from internal
carry organs.
both
#
sup, and deep lymph vessels go Lymphoid Organs
through lymph nodes.
y yo 2
affarent efferent y
↑
*Ye
I Bone Marrow:
B
cells:
originate and mature
Spleen. Tonsils. Vermiform
empty to
lymphatic
trunks
I cells:
only originate #Lymbocytes mature in
1"orgent
last location
final maturation (antigen-depen
T cells
lymphatic ducts S
=>
Thymus: mature
duct:r
1) rightlymphatic upperlimb,
head, chest development of called
lymphocytes
#
2) thoracic duct:rest of
body Antigen-native development. -
carried
↓ to functions
notes: bloodstream
vessels H
lymphatic fluid balance:drain extra fluid
->
one-way
-
I' (ex. s
lymp. lymph.organs large molecules
->
too
V.-> RO
pump. carry
lymp.r. -> have VALVES (preventflowing backward ->
immune survalance and fight pa
lymp. v. ->
Open system
#
lymphatic system -> route fat
of transportation, which ab
Clinical of
lymph
absorbed - packaged
fats ->
chylomicrons -lymph capillaries ->
lymph ve
->
=>
lymphoma -
enlarged
node
, Spleen
6:Germinal Centre
lymphocytes
-> White Pulp
↓
-
Red Pulp cells
T cells
B
Is -
cortex
-
paracortex
perishes PALS
-
-
Histology of Lymph Nodes 1
200-450 L.M.
medullary cords body
·
in our
Medulla sinuses
·
encapsulated Jelastin and collagen)
·afferentvessels the trabecular Trabecular
godeep by of cortex. continue
-> cords populated by B and T cells.
-> luminal surface sinuses
of contain Cortex trabecular sinus
reticular cells ->
final point
offiltration. -> made subscapular
of and cortical sinuses and lymph nodules
->
medullary sinuses are continuations
-Mph-> subscapulos. -> corticals.
cortical
of sinuses. They eventually APCs, antigens, lymphocytes lymphatic tissue
-
form efferent vessels.
through endothelium of cortical laye
->
Trabecular layer has T-helper, is cells -> more in than I cells.
cortex
* of values:
function
⑱
flow lymph- afferent L.N.- efferent. ->
Primary follice:small dormant lymphocytes.
-
of ->
secondary fullice:heterogenous mix activated large
-> of B cells.
-> Germinal Center Mantle Zone:inactive B cells, follicular dendritic cells (FD
have 3 zones: Montle, light, dark - ↓
meanstermeland
may mature into
or
plasma cells and
mode
stay in
LightZom:contain centrocytes
-
with
interact FDC
B cell, T-helper and help to
my clean up.
Dark Zone:contain centroblasts source cells
->
for
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