Roitt MCQs FINAL TEST 2023.
Which of the following does NOT protect body surfaces:
A Skin
B Mucus
C Gastric acid
D Salivary amylase
E Gut microflora - ANSWER D - Salivary amylase does not protect body surfaces, as enzymes assist in digestion only. All others influence environment.
Pattern ...
Roitt MCQs FINAL TEST 2023.
Which of the following does NOT protect body surfaces:
A Skin
B Mucus
C Gastric acid
D Salivary amylase
E Gut microflora - ANSWER D - Salivary amylase does not protect body surfaces, as enzymes assist in digestion only. All others influence environment.
Pattern recognition receptors (PRR) include:
A LPS.
B PAMPs.
C Lipoteichoic acid.
D Lectin-like molecules.
E Unmethylated CpG sequences. - ANSWER D - PAMP includes Lectin-like molecules. PCR recognises exposed microbial sugars.
The mononuclear phagocyte system does not include:
A Monocytes.
B Kupffer cells.
C Kidney mesangial cells.
D Lymph node medullary macrophages.
E Endothelial cells. - ANSWER E - Endothelial cells, which are not essentially phagocytic although they do contribute by the production of mediators of the inflammatory process, particularly acute inflammation
A polymorphonuclear neutrophil (PMN):
A Is a bone marrow stem cell.
B Is closely similar to a mast cell.
C Contains microbicidal cytoplasmic granules.
D Is not a professional phagocytic cell.
E Has granules which stain with eosin. - ANSWER C - The polymorphonuclear neutrophil (PMN) contains microbicidal cytoplasmic granules, where the granules contain a wide spectrum of microbicidal agents.
Which of the following is not produced following activation of the NADPH oxidase microbicidal pathway:
A O2 -
B O2
C H2O2 D NO
E OH - ANSWER D - Nitrous oxide is produced following the induction of nitric oxide synthase, whereas Oxygen, alcohols and hydrogen peroxide are produced following activation of the N A D P H oxidase microbicidal pathway.
Neutrophil defensins are:
A Anti-toxins.
B Oxygen-dependent.
C Enzymes.
D Glycolipids.
E Peptide antibiotics. - ANSWER E - Neutrophil defensins are peptide antibiotics which present in the granules in extremely high concentrations
The TLR9 pattern recognition receptor recognises:
A CpG motifs.
B Gram +ve peptidoglycan.
C Mycobacterial lipoarabinomannan.
D Gram -ve LPS.
E dsRNA - ANSWER A - Toll-like receptor 9 recognition of CPG motifs, microbial dinucleotide sequences, leads to activation of the NFkB transcription factor
Complement component C3 is cleaved by:
A C3b
B C3bBb
C Factor B
D Factor D
E Factor H - ANSWER B - C3bBb is the C3 convertase enzyme generated in the alternative complement pathway and is responsible for splitting off the small peptide C3a leaving C3b as a residue.
The membrane attack complex consists of:
A OH.
B Colicins
C C3b3b,Bb
D C5b,6,7,8,9
E Properdin - ANSWER D - The membrane attack complex consists of C5b, C6, C7, C8, and C9 - the Cterminal components form a complex which inserts into the membrane to form a transmembrane ion channel which leads to lysis of the cell.
C3b:
A Is chemotactic.
B Is an anaphylatoxin.
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