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Summary Citric acid cycle
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The citric acid cycle, also known as the Krebs cycle or TCA cycle, is an important metabolic pathway thatoccurs in the mitochondria of eukaryotic cells. This cycle plays a critical role in the production of energy
and the metabolism of biomolecules. In this article, we will explore the details of this cycle and the
enzymes involved in each step.
Overview of the Citric Acid Cycle
The citric acid cycle is a series of chemical reactions that occur in the mitochondria of eukaryotic cells.
The cycle begins with the conversion of acetyl-CoA to citrate, which is then oxidized through a series of
steps to produce ATP, NADH and FADH2. The cycle also produces carbon dioxide as a waste product.
Enzymes Involved in the Citric Acid Cycle
The citric acid cycle involves several enzymes, including:
Citrate synthase
Aconitase
Isocitrate dehydrogenase
Alpha-ketoglutarate dehydrogenase
Succinyl-CoA synthetase
Succinate dehydrogenase
Fumarase
Malate dehydrogenase
Steps of the Citric Acid Cycle
The citric acid cycle consists of several steps, including:
Acetyl-CoA to Citrate: Acetyl-CoA combines with oxaloacetate to form citrate in a reaction catalyzed by
citrate synthase.
Citrate to Isocitrate: Citrate is converted to isocitrate in a reaction catalyzed by aconitase.
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