Presentation NR 546 Week 2 Assignment; Neurotransmitter Table 2022
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Presentation NR 546
Presentation NR 546 Week 2 Assignment; Neurotransmitter Table 2022
* To be completed throughout course and submitted in Week 8*
Neuro transmitter Receptor Subtype Location/Function/Effects
/symptoms of excess or deficit if applicable Distribution (ie: CNS/PNS,
GI, vascular) Drug classes that ...
presentation nr 546 week 2 assignment neurotransmitter table 2022 to be completed throughout course and submitted in week 8 neuro transmitter receptor subtype locationfunctioneffects symptoms
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Presentation NR 546 Week 2 Assignment; Neurotransmitter Table 2022
* To be completed throughout course and submitted in Week 8*
Neuro Receptor Location/Function/Effects Distribution Drug classes that Specific medications that target this
transmitter Subtype /symptoms of excess or (ie: CNS/PNS, target this neurotransmitter or receptor
deficit if applicable GI, vascular) neurotransmitter or
receptor
Glutamate AMPA α-Amino-3-hydroxy-5- CNS AMPA Receptor Perampanel
methyl-4- Antagonists
isoxazolepropionic acid
(AMPA)-type glutamate
receptors (AMPARs)
mediate the majority of
fast excitatory synaptic
transmission in the
brain.
AMPA receptors are
abundant and widely
distributed in the
central nervous system.
Hippocampus, outer layer
of the cortex, basal
ganglia, olfactory regions,
lateral septum, and
amygdala of the CNS are
all enriched with GluA1,
GluA2, and GluA3
subunits.
MNDA N-methyl-D-aspartate CNS NDMA Glutamate NDMA Glutamate
(NMDA) receptors NMDA receptors Antagonist Antagonist-
represent one of the are found in Memantine
ligand-gated non-selective both synaptic Phencyclidine
ionotropic glutamate and Ketamine
receptors (iGluRs), which extrasynaptic Dextromethorphan
Dextromethadone
, are present in high density locations on
within the hippocampus neurons. NMDA
and the cerebral cortex receptors also
N-methyl-D-aspartate can be found on
(NMDA) receptors, a neurons in early
family of L-glutamate stages prior to
receptors, play an synaptogenesis,
important role in learning where they may
and memory, and are be involved in
critical for spatial migration and
memory demonstrated differentiation.
deterioration in NMDA Extrasynaptic
receptor subunit NMDA receptors
expression and function typically are
with advancing age associated with
contacts with
adjacent
processes such
as axons and
glia
GABA GABA a Limbic system GABAa Benzodiazepines Zolpidem
GABAa is considered in receptors are Neuroactive Steroids Zaleplon
fast synaptic inhibition. located Zopiclone
throughout the Eszopiclone
central nervous Allepregnanolone
system
Serotonin 5HT 1a 5HT1A receptors are CNS partial 5-HT1A-R buspirone, gepirone, and
5HT located on GABA agonists tandospirone
interneurons in the
prefrontal cortex
5HT1A receptors
can
promote the release of
, other neurotransmitters.
5HT1A receptors are
always inhibitory, but
they are very frequently
localized upon
postsynaptic GABA
neurons, which means
that the net downstream
effect in this case is
actually excitatory
Excess
Psychosis mood imbalance
anxiety
5HT 1B 5HT1B receptors are CNS Serotonin 1b Almotriptan
inhibitory and can Receptor Zolmitriptan
specifically inhibit Agonists Sumatriptan
neurotransmitter release Naratriptan
from norepinephrine, Rizatriptan
dopamine, histamine, and Frovatriptan
acetylcholine neurons Eletriptan
when these receptors are
localized upon
presynaptic nerve
terminals of these
neurons
Imbalance causes
Depression
5HT 1d 5-hydroxytryptamine CNS Serotonin 5-HT1D Antipsychotics
(serotonin) receptor 1D, Receptor Antagonists Ziprasidone
also known as HTR1D, is Antipsychotics Paliperidone
a 5-HT receptor, but also Clozapine
denotes the human gene Aripiprazole
encoding it. 5-HT1D acts Yohimbine
on the central nervous Risperidone
system, and affects
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