A literature review is a type of document that summarizes and synthesizes the existing research on a specific topic. It usually forms part of a larger research project, such as a thesis or dissertation, and its purpose is to provide context and background information on the topic being studied. A l...
Colorectal cancer (CRC) is considered the fourth directing reason for cancer-related
casualties around the. There are several reasons for CRC to prevail, but the primary reason is the
liver metastasis for mortality in CRC patients, arising in about 60% of patients with no helpful
therapies. MicroRNAs (miRNAs) are significant regulators for gene expression and cellular
homeostasis (Xio, et al., 2008). This review presents the sent of studies that were identified,
observed, and reviewed to provide an in-depth study on the role of miRNA in colorectal cancer
and specify the clinically related miRNA,s and evaluate their potential aim in targeting colorectal
cancer.
It has been noted by Ye, et al., (2019), the essential part of miRNAs in the pathogenesis
of cancer has been adequately reported that involves CRC and related disease. miRNAs are
realized as targets for genomic-based lesions, which are mostly inactivated tumor suppressors,
activated oncogenes, and cancer cells that result in epigenetic silencing, amplification, and
deletion. Besides that, miRNAs are recognized to manage the suppressor signaling pathways and
the oncogenic. More than that, it participates in the proliferation, metastasis, and growth invasion
of cancer cells. Several functional types of research have reported the anti-tumorigenic
properties of particular miRNAs presented in cancer cells, and their probability to be used as
unique anti-cancer molecules. Few of the miRNA-based medications have already been attained
to enter the phase 2 clinical trials. According to Danese, et al., (2017), nearly 30% of human
genes are under the supervision of small molecules known as microRNAs. These molecules
work to impede specific genes to modify into essential proteins and govern most necessary
procedures like cell development and division. However, their process to accomplish so is still
unclear. Presently various researchers have worked with the European Molecular Biology
Laboratory (EMBL) have formulated a recent technique that disclosed the procedure of effort for
microRNAs within a test tube.
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