Immunology notes detailing immunological pathologies and conditions. Notes made from multiple resources such as oxford handbook, question banks, university lectures and UK guidelines.
Look at specialty section and content list for the summary contents of this file.
, Hypersensitivity Reaction
Type Mechanism Example
Anaphylaxis
Type I - Anaphylactic Antigen reacts with IgE bound to Mast cells Atopy (E.g. Eczema, Asthma, Allergic Rhinitis)
Urticaria
Autoimmune Haemolytic Anaemia
ITP
Goodpasture's Syndrome
Type II - Cell Bound IgG or IgM binds to antigen on cell surface Pernicious Anaemia
Acute Haemolytic Transfusion Reactions
Rheumatic Fever
Pemphigoid
Serum sickness
SLE
Post-Streptococcal Glomerulonephritis
Type III - Immune
Free antigen and Antibody (IgG / IgA) combine Extrinsic Allergic Alveolitis (esp. acute phase)
Complex
RA / PAN
Henoch-Schonlein Purpura
Farmer's Lung
Tuberculosis / Tuberculin skin reaction
GVHD
Allergic Contact Dermatitis
Type IV - Delayed
T-Cell Mediated Scabies
Hypersensitivity
Extrinsic Allergic Alveolitis (esp. chronic phase)
Multiple Sclerosis
Guillain-Barre Syndrome
Type V - Antibody Antibodies recognise and bind to cell surface Grave's Disease
Receptor Complexes receptors leading to stimulation or blockade Myasthenia Gravis
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