MODULE 1
1. What are the BON rules and regulations for prescriptive authority for the advance practice nurse?
1. Texas is very restricted
2. Describe the pharmacokinetic processes of absorption, distribution, metabolism and elimination and how differences in these areas affect drug action.
1. A...
1 what are the bon rules and regulations for prescriptive authority for the advance practice nurse
2 describe the pharmacokinetic processes of absorption
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University Of Texas - Arlington
NURS 5344 (NURS5344)
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PHARM STUDY GUIDE QUIZ 1- ALL ANSWERS 100%
CORRECT SPRING FALL-2022 LATEST SOLUTION
GUARANTEED GRADE A+
MODULE 1
1. What are the BON rules and regulations for prescriptive authority for the advance
practice nurse?
1. Texas is very restricted
2. Describe the pharmacokinetic processes of absorption, distribution, metabolism and
elimination and how differences in these areas affect drug action.
1. Absorption
1. Drug’s movement from the site of administration into the blood.
2. Distribution
1.Drug’s movement from the blood into the interstitial space oftissues
and from there into cells.
3. Metabolism
1.Biotransformation is the enzymatically mediated alteration of drug
structure.
4. Elimination
1. Combination of metabolism and excretion
3. Compare and contrast pharmacokinetics and pharmacodynamics of special
populations—pediatrics, older adults and those that are pregnant.
1. Pediatrics—they have organ immaturity, elderly—they have organ degeneration,
loss of nephrons, excretion of drug is decreased and you have to give this
population a lower dose of medication. Medication can pass through milk of
lactating females.
4. Analyze a drug interaction to determine an appropriate course of action.
1. Basic mechanism of drug-drug interactions through pharmacokinetic interactions
are altered absorption, altered distribution, altered metabolism, and altered renal
excretion.
5. Identify medications with a narrow therapeutic index requiring drug level
monitoring.
1.
6. Discuss the effect of ionization and pH on absorption.
1. Drugs that are weak acids are best absorbed in acidic environments. Acidic drugs
accumulate on the alkaline side, basic drugs accumulate on the acidic side known
as ion trapping. Ionization of the drugs is pH dependent, when the pH and the
fluid on one side of the membrane differs from the pH on the other side, drug
molecules tend to accumulate on the side where the pH most favors ionization.
7. Discuss factors affecting drug distribution.
1. Competition for protein binding and alteration of extracellular pH
8. Discuss barriers affecting drug distribution—such as placental membrane, blood
brain barrier and volume of distribution.
1. Placental membrane: drugs are easily passed through the placental membrance
2. Blood brain barrier: the PGP pumps drugs back into the blood and thereby limits
their access to the brain.
3. Volume of distribution:
9. Discuss the “first-pass effect”—what effect can this have on distribution of a drug?
1. Rapid hepatic inactivation of certain oral drugs. When drugs are absorbed by the
, GI tract, they are carried directly to the liver through the hepatic portal vein
before entering the systemic circulation. If the capacity of the liver to metabolize
the drug is extremely high, this drug can be completely inactivated on its first pass
through the liver.
10. Discuss the significance of the Cytochrome P450 system on metabolism of drugs.
1. It is a group of 12 closely related enzyme families. CYP1, CYP2, CYP3
metabolize drugs. The other 9 families metabolize endogenous compounds (ex.
Fatty acids, steroids).
11. Discuss the major hepatotoxic drugs and possible effects on drug metabolism.
1.
12. List various routes of drug elimination—review normal renal function including
glomerular filtration, passive tubular reabsorption and active tubular secretion;
describe the implications on drug clearance and how elimination affects prescribing.
1.
13. Discuss terms used to describe drug actions-agonist, partial agonist, antagonist.
1. Agonist: molecules that activate receptors
2. Partial agonist: Only has moderate intrinsic activity. Maximal effect that a partial
agonist can produce is lower than that of a full agonist.
3. Antagonist: Produce their effects by preventing receptor activation by endogenous
regulatory molecules and drugs.
14. Discuss the impact of food on drug absorption, drug metabolism and on drug toxicity
and action—as well as the timing of drug administration.
LIFESPAN
1. Hepatic metabolism and GFR increase during pregnancy, dosages of some drugs
may need to be increased.
2. Rate of albumin to water decreases
1.Third trimester: Renal blood flow is doubled and renal excretion is
accelerated (drugs excreted rapidly)
2. Tone and mobility of bowel decrease
3. Prolongation of drug effects Total (½ life increases)
3. Understand stages of development in pregnancy
1. Conception: through week 2
2. Embryonic period: week 3-week 8
a) Gross malformations can be produced by teratogens
3. Fetal period: week 9-delivery
4. Understand pregnancy labeling
1. 3 categories now
a) Pregnancy, lactation, male & female reproductive potential
5. How do you decrease risk in the infant during breastfeeding?
1.Take meds immediately after breastfeeding, avoid drugs that havelong
half-lives, choose drugs that tend to be excluded from milk, avoid drugs
that are known to be hazardous.
6. How do pediatric patients differ in their response to medications?
1. Absorption
a) Oral?
, 1. Neonates: drug remain in the stomach longer which
increases the levels, low acidity can affect the absorption of
acid labile drugs
b) Parenteral?
1. Reponses are slow and erratic.
2. Infancy: absorption is more rapid than in neonates & adults
3. Best avoided in infants
c) Transdermal?
1. Greater skin permeability which increases topical drug
absorption and increases the risk for toxicity
2. Distribution
a) Protein binding
1. Neonates: less protein-binding—increased availability of
highly protein bound drugs such as phenytoin, diazepam,
and phenobarbital. Reduced dosages needed in these highly
bound drugs.
b) Blood Brain Barrier
1. Not fully developed at birth, drugs have easy access to the
CNS, doses should be reduced.
3. Metabolism
a) Hepatic function?
1. Liver hasn’t reached full maturation—sensitive to drugs
eliminated by the CYP450. Liver’s ability to metabolize
drugs increases about one month after birth.
b) T half life
1. Decreased by as much as 48-72 hours
4. Excretion
a) Renal?
1. GFR is significantly reduced at birth, drugs eliminated by
the kidneys must be given in a reduced dosage and longer
dosing intervals.
7. What education needs to be given to parents?
1. What to do if child spits out medication or throws it up
2.Effective education: dosage size and timing, route, technique of
administration, duration of treatment, how to store the drug, nature and
time course of the desired response, nature and time course of adverse
reactions.
8. How do you convert pounds to KG?
1. Divide weight by 2.2
9. What is definition of polypharmacy? Is polypharmacy always inappropriate?
What is Beer’s List?
1.Polypharmacy: 3 or more prescription drugs in conjunction-+ with3 or
more dietary supplements.
2. No
3.List that identifies drugs with a high likelihood of causing adverseeffects
in the elderly
, 10. What are pharmacodynamic and pharmacokinetic differences in geri patients?
1. Absorption?
a) GI
1. Produce less acid and fewer parietal cells
2. Bioavailability decreased
3. Rate of absorption decreased
2. Distribution?
a) Lean Body Mass
1. Drugs accumulate in adipose tissues because lean muscle
mass decreases by 20%
b) Body Water
1. Decrease by 10-15%-drugs reach higher serum
concentrations
c) Albumin
1. Lowered—leads to higher levels of free or unbound drugs
3. Metabolism?
a) Hepatic
1. Decreased with age—decreases drug clearance
b) T half life
1. Increases—alters drug-drug interactions
4. Excretion?
a) Renal
1. Decreases—which decreases renal clearance of drugs
■ Bacteriostatic:
ECSTaTiC ANTIMICROBIALS
■ E rythromycin
■ C lindamycin
1. Differentiate Bacteriostatic and Bactericidal.
■ Sulfamethoxazole 1. Bacteriostatic: can slow bacteria growth and do NOT cause cell
■ T rimethoprim death
■ a 2. Baterialcidal: directly lethal to the bacteria
■ T etracycline 2. What is the difference between broad spectrum and narrow
■ i
■ C hloramphenicol spectrum?
■ Bacterialcidal: 1. Broad spectrum: active against a wide variety of microbes.
Very Finely 2. Narrow spectrum: only active against a few species of bacteria or
Proficient At Cell micro-organisms
Murder
■ V ancomycin
3. Which is preferred?
■ F luoroquinolones 1. Narrow spectrum
■ P enicillin 4. What are antibiotic classifications?
■ A minoglycosides 1. Classifications by susceptible organisms
■ C ephalosporins 2. Classified by mechanism of action
■ M etronidazole 5. What is empiric antibiotic use? Therapeutic use?
1. Initiate treatment before you know what the results of the test--
Treat with broad-spectrum antibiotic for initial treatment and
once you get culture and drug sensitivity then you can use
narrow spectrum antibiotic.
6. Which antibiotics work by weakening the cell wall?
1. Penicillins
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