(Solution) NURS 6630 week 2 Discussion: Foundational Neuroscience As a psychiatric nurse practitioner, it is essential for you to have a strong background in foundational neuroscience. In order to dia gnose and treat patients, you must not only understand the pathophysiology of psychiatric disorder...
Explain the agonist-to-antagonist spectrum of action of
psychopharmacologic agents, including how partial and inverse agonist
functionality may impact the efficacy of psychopharmacologic
treatments.
The traditional drug-receptor theory is a concept of how drugs abide, drug-
receptor interaction, and agonists' actions and antagonists with affinity and intrinsic
efficacy (Berg, & Clarke, 2018). Berg and Clark's study of the theory found that drugs
can act as antagonists or agonists. In contrast, agonists drugs have intrinsic efficacy and
affinity, and antagonists have only relationship and no inherent effectiveness. The authors
noted that the antagonists decrease the probability of agonist drug occupancy by
occupying the receptor cells. Still, the increased agonist concentration leads to the agonist
increasing receptor occupancy, thus blocking antagonists' effects. A full agonist generates
the maximal response a system is capable whereas a partial agonist produces a
submaximal reaction; However, a partial agonist's intrinsic efficacy is less than that of a
full agonist; full agonists can also differ in inherent efficacy. Lastly, the spare receptors or
receptor reserve is the ability of an agonist can produce a maximum response without
occupancy of the entire receptor population due to saturation of post-receptor signaling
mechanisms,
Compare and contrast the actions of g couple proteins and ion gated channels.
Ion gated receptors have a key role in the nervous system for signaling, allowing
rapid and conversion of chemical neurotransmitter messages to electrical current with ionotropic
receptors regulated by protein-protein interactions with other ion channels, G-protein coupled
receptors and intracellular proteins (Li et al., 2014). Li et al. found that the G Protein interactions
with ion channel receptors can increase the capacity of neuronal signaling cascades and represent
This study source was downloaded by 100000849840424 from CourseHero.com on 07-27-2022 00:19:10 GMT -05:00
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller ProfGoodlucK. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.99. You're not tied to anything after your purchase.
