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Cytoskeleton of cells
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Lecture notes of 11 pages for the course Medicine at QUB (Biochemistry)
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CYTOSKELETON Iiiprotein filaments that extends
throughout
the
cytoplasm EUKARYOTIC CELLS
Have 3 main filaments
Intermediate filaments Ct
Microtubules
Actin microfilaments
Form a network of fibres
1 INTERMEDIATE in the cell that provide
tensilestrength They allow cells to resist external
forces such as stretching Main properties are
keratin vimen tin and I am ins Name from
comes
the size of the filaments in muscle in between actin
and myosin They are the toughest fibres in the cell
and have a role in
tethering cells to other cells
key
, IF fibres connect cells to
each other via contact points
known as DESMOSOMES
D es mo Somes allow
cells to form sheets
Epithelial
and
spread the stress points
on a cell to minimize damage due to mechanical strain
IFS are made of long twisted polymers of protein
Subunits
2monomers I dinner
Gives the lF
great
strength
412 dimers These IF tetramers
packedtogether to
8 2tetramers on to form a
go
helical array
containing 8 strands
of tetramers forming a rope like filament
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