Chamberlain College of Nursing: NR 565 MidTerm Review_ LATEST 2021/2022,100% CORRECT
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NR 565
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NR 565
Chamberlain College of Nursing: NR 565 MidTerm Review_ LATEST 2021/2022
MidTerm Review
1. G-Protien coupled receptors and how they interact with drugs
G-protein coupled receptors (GPCR) interact with drugs through 7 regions of proteins that span and innervate the cell membrane, and trap...
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Chamberlain College of Nursing: NR 565 MidTerm Review_
LATEST 2021/2022
MidTerm Review
1. G-Protien coupled receptors and how they interact with drugs
G-protein coupled receptors (GPCR) interact with drugs through 7 regions of
proteins that span and innervate the cell membrane, and trap the molecule into
the receptor site like an interwoven basket (Insel & Sriram, 2018). Drugs can then
enter thisspace and interact with the GRCP. A specific interaction and binding
with a site on one or more of the regions of proteins within the GPCR, and drugs
bound with the GRCP can stimulate the release of G proteins that can interact
with various effector proteins tocreate physiological responses within the body
(Insel & Sriram, 2018). This process occurs through secondary messengers (such
as cAMP) which creates the extracellular interactions produced by the drug
binding to the GRCP.
2. What neurotransmitters are excitatory?
amino acids such as glycine, aspartate, and glutamate are excitatory (Woo &
Robinson, p.16, 2016).
3. Which is the most common CYP enzyme in the body? What role does
itplay?
According to the textbook, the CYP3A4 is the most important enzyme in the
body.
CYP3A4 is responsible for the metabolism of more than 50% of medications and is
considered a major drug metabolizing enzyme. CYP3A4 can be found in the liver,
as well as the lining of the GI tract. Due to this location, food can also influence
this CYP. One example of this is grapefruit juice, which can inhibit CYP3A4.
Medications that aremetabolized by CYP3A4 include antimicrobials, calcium
channel blockers, antihistamines, anticonvulsants, azole antifungals, and
corticosteroids (Woo, & Robinson, 2016).
4. What is the clinical significance of being an ultra-rapid
CYP2D6metabolizer?
People who are ultra-rapid metabolizers have high activity of CYP2D6 enzymes
thatbreak down certain medicines rapidly and are likely to need different doses or
even a different medicine. Drug dose, response, and toxicity risk of beta-blockers,
antidepressants, antiarrhythmics, and opioid analgesics are dependent on
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, CYP2D6 pharmacogenetics (Ayazseven et al., 2020). Knowing the result of the
CYP2D6 test andwhich group the patient falls into such as poor metabolizers,
intermediate metabolizers,or ultra-rapid metabolizers, will help nurse
practitioners prescribe the right medication and dosage for the patient.
5. What would be the concern if a drug is a CYP450indicer? How that
mightaffect the metabolism of other drug the patient is taking?
Cytochrome P450 enzymes are in cells throughout the body, primarily found in
liver cells (Girvan & Munro, 2016). These enzymes are essential for the
metabolism of manymedications. Cytochrome P450 enzymes can act as an
inducer or inhibitor of metabolism. When a medication induces the CYP450
enzyme that increases the rate of
This study source was downloaded by 100000802531269 from CourseHero.com on 03-05-2022 13:05:01 GMT -06:00
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