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BIOCHEM 1005 Final Exam Questions and Answers- University of New England

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  • February 28, 2022
  • 20
  • 2021/2022
  • Exam (elaborations)
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Acids are often produced in the body as metabolic end products. These acids are
neutralized in the blood, which depletes the blood's ________ supply.

CO2

A 25 year old female is diagnosed with sandfly fever. The combination of the
infection and the increase in cortisol increased protein catabolism. In this
individual you would predict nitrogen balance to be:

Correct
negative

Samantha is a 24 year old female with type 1 diabetes. She could not recall
whether she took her insulin injection after dinner and accidentally administers
an additional dose of insulin. Twenty minutes later she feels dizzy and tests her
blood glucose which was 55 mg/dl, (normal 75 - 105 mg/dl). The presentation of
hypoglycemia is initially and most immediately due t

increased glucose uptake by GLUT4

Glutamine is metabolised to biocarbonate ion in the ________ to replenish this
important component of the blood buffering system.

kidneys

What type of reaction is shown below?
Amino acid + alpha -Ketoglutarate yeilds alpha-Keto acid + Glutamate

Transamination

A 16-year-old girl complains that she often feels light-headed and dizzy just
before lunch at school. She tells you that she often does not eat breakfast. She
almost always feels better after lunch. You explain to her that she is experiencing
hypoglycemia.
Under conditions of hypoglycemia:

cortisol is increased

A 16-year-old girl complains that she often feels light-headed and dizzy just
before lunch at school. She tells you that she often does not eat breakfast. She
almost always feels better after lunch. You explain to her that she is experiencing

,hypoglycemia.
Under these conditions, you would expect:

glycogen phosphorylase kinase to be phosphorylated and active

A patient is experiencing uncontrolled diabetes mellitus with an overproduction
of β-hydroxybutyric acid (ketones) and deep breaths (Kussmauls) Which
statement is false?

The basic amino acids, lysine and arginine, neutralize the β-hydroxybutyric acid in the blood.

Which statement is false about the amino acid pool?

The pool of amino acids is strictly controlled, similar to blood glucose

All of the following enzymes can either 'fix' free ammonia or release free
ammonia except:

alanine aminotransferase

The activation of pancreatic zymogens required for protein digestion is initiated
by which enzyme:

enteropeptidase

What compound will stimulate activity thru the urea cycle:

arginine

Which of the hormones signals through Tyrosine Receptor Kinases (TRK)
receptors?

insulin

The thyroid is unique as it can store thyroid hormone within the colloid space.
Within the space the thyroid hormone is primarily stored:

as part of the thyroglobin protein

Thyroid peroxidase mediates coupling of and iodination of thyroglobulin,
essential steps in creating thyroid hormones. Which coupling reaction is
associated with the correct hormone product?

Condensation of monoiodotyrosine with diiodotyrosine to make triiodothyronine

, When an LDL particle is taken up by the cell, what impact will this have on the
regulation of de novo cholesterol synthesis?

SREBP:SCAP will be bound to the endoplasmic reticulum

Samantha is a 24 year old female with type 1 diabetes. She could not recall
whether she took her insulin injection after dinner and accidentally administers
an additional dose of insulin. Twenty minutes later she feels dizzy and tests her
blood glucose which was 55 mg/dl, (normal 75 - 105 mg/dl). The presentation of
hypoglycemia is initially and most immediately due to:

increased glucose uptake by GLUT4

Which of the following enzymes is responsible for the conversion of ethanol to
acetaldehyde in the cytosol?

Alcohol dehydrogenase

Which of the following is the regulated step of fatty acid synthesis in eukaryotes?

Carboxylation of acetyl CoA.

The glucose alaine cycle is a method of transfering ammonia from the skeletal
muscle to the liver. In this process the non-toxic carrier of ammonia is which of
the following compounds?

alanine

Several friends went out Saturday evening to celebrate an exam. They skipped
dinner and decided to head straight to the bar. The next morning Jo Blow found
his roommate, Al Martini, laying unconscious at the bottom of the stairs. He was
rushed to the ED and initial laboratory studies showed a metabolic acidosis and
blood glucose levels of 30mg/dL (normal range 100-120mg/dL).
If you were able to measure levels of oxaloacetate in Al at this point in time they
would be:

decreased in the mitochondria; decreased in the cytosol

When glucagon is elevated is Fructose 2,6 bisphosphatase phosphorylated and
active?

Yes

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