BIOCHEM 1005 Unit 2 Test Questions and Answers- University of New England
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BIOCHEM 1005
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BIOCHEM 1005
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Which of the following enzymes is part of both the TCA cycle and ETC?
• Succinate dehydrogenase
The majority of energy in ATP is stored within which of the following bonds below?
• 1
In the case of deficiency in phenylalanine hydroxlase which of the following amino acids will become essential
• Tyrosine
HFI is a rare recessive disorder. Which of the following is not a consequence of this enzyme deficiency?
• They will have low blood sugar (hypoglycemia), especially after eating fruits, fructose, sucrose, jaundice, excessive
sleepiness, convulsions, irritability
When the pancreatic beta cells sense an increase in glucose, the release of insulin is facilitated through which of the following mechanisms?
• Increase in intracellular calcium
During aerobic exercise, intracellular calcium increases and which of the following will occur?
• Isocitrate dehydrogenase and alpha-keto glutarate dehydrogenase are allosterically activated by increase in
calcium Within the red blood cell, the lack of which of the following compounds can result in exercessive hemolysis and
jaundice?
• NADPH
After fasting for 6 hours which of the following would be consistent with hormone levels of this individual?
• Insulin (-), Glucagon (+), Cortisol (+), Epinephrine (+)
There is a gain of function mutation in the insulin receptor substrate that makes it permanently bound to the insulin receptor substrate that
makes it permanently bound to the insulin receptor. Which of the following may occur as a result of this mutation.
• Increase in protein kinase B activity
Which of the following activators is correctly paired with the enzyme that activates it?
• Fructose-2,6-bisphosphate : phosphofructokinase 1
• NOT:
o Glucose-6-phosphate : hexokinase
o ATP : alpha-ketogluterate dehydrogenase
o ATP : pyruvate kinase
o Citrate : citrate synthase
Fructose 1,6 bisphosphate will enhance the activity of which of the following enzymes?
•
Under fed conditions, glucose taken up by the liver is primarily used for which of the following processes?
• It is used as a substrate for liver glycogen synthesis
In the malate aspartate shuttle, cytosolic oxaloacetate is to form as a means of moving reducing equivalents across
the mitochondrial membrane.
•
Which of the following process is considered to be catabolic?
• Glycogenolysis
In an individual with a deficiency in PDC, which of the following reactions would be directly impaired?
• Pyruvate Acetyl CoA
Monocytes are unique cells that secrete the cytokine, interleukin-1. Once released, this cytokine will bind a receptor on the outside of the
monocytes and regulate its response. In this situation interleukin-1 is best described as which of the following?
• An autocrine signal
NADH generated in the cytosol must be transported across the mitochondrial membrane in order to be oxidized by the electron transport
chain. Which of the following shuttles or transporters can be used to facilitate the movement of cytosolic NADH into the mitochondria?
• Malate-aspartate shuttle
Based on the following schematic what will the charge be on guanine pH of 10?
• -2
Which of the following is an example of mechanical work?
• Cleavage of high energy phosphate bond to facilitate muscle contraction
Which of the following TCA cycle intermediates is directly used to synthesize
heme?
• Succinyl CoA
Which of the following hormones will facilitate activation of protein kinase A?
• Activation of G protein, activation of adenylate cyclase, production of cAMP
• Glucagon
• Epinephrine
The ribonucleic reductase is regulated at both an activity site and a substrate specificity site. Which of the following compounds must
always be bound to the activity site for an enzyme to be active?
• ATP
An individual consumes a breakfast consisting of cereal, eggs, sausage, pancakes and maple syrup. After this meal, which of the following
statements best summarizes his metabolic state?
• Fructose 2,6 bisphosphate will be elevated
Which of the following digestive enzymes is primarily responsible for digesting large polysaccharides chains into smaller oligosaccharides?
• Alpha amylase
Sickle cell is caused by a single point mutation that changes a glutamic acid to a valine. This type of mutation is best categorized as which of
, the following?
• Missense mutation
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