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Haematopoiesis and introduction to blood cells
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Lecture notes on Haematopoiesis and introduction to blood cells
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Αἲμα – bloodλόγος-study
Haematology is the branch of science concerned with the study of
blood, blood-forming tissues and the disorders associated with them
Blood composition
Haematopoiesis
All cells of the blood originate from multipotent stem cells in the bone marrow - haematopoietic stem cells (HSCs)
1. Erythropoiesis: the formation of red blood cells
2. Myelopoiesis: the formation of white blood cells
3. Thrombopoiesis: the formation of platelets
Stem cells are undifferentiated cells that have two unique features:
1. Capacity of self-renewal
2. Ability to differentiate into a variety of mature cell types
, - HSCs are rare, ≈ 1 in every 20 million nucleated cells in the bone marrow
- Long-term HSCs: able to repopulate the bone marrow for › 16 weeks
- Short-term HSCs: engraft transiently for few weeks
- CD34+ CD38- LIN- = Appear like a medium size lymphocyte
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