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GNUR 294 FINAL EXAM- Pharmacotherapy of Alzheimers & Seizures / GNUR294 FINAL EXAM- Pharmacotherapy of Alzheimers & Seizures:NEWEST-2022 $12.99   Add to cart

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GNUR 294 FINAL EXAM- Pharmacotherapy of Alzheimers & Seizures / GNUR294 FINAL EXAM- Pharmacotherapy of Alzheimers & Seizures:NEWEST-2022

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GNUR 294 FINAL EXAM- Pharmacotherapy of Alzheimers & Seizures / GNUR294 FINAL EXAM- Pharmacotherapy of Alzheimers & Seizures:NEWEST-2022GNUR 294 FINAL EXAM- Pharmacotherapy of Alzheimers & Seizures / GNUR294 FINAL EXAM- Pharmacotherapy of Alzheimers & Seizures:NEWEST-2022GNUR 294 FINAL EXAM- Pharma...

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  • February 8, 2022
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  • 2021/2022
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GNUR 294 FINAL EXAM

Pharmacotherapy of Alzheimer’s Disease
 Builds up these plaques and deposited between the nerve cells
 When between the nerve cells cannot transmit nerve signals
 Develop mainly in the area in which you learn and retain new information
 Long term memory can stay intact, but the ability to learn new information is affected
 The nerve fibers and cells become tangled
 Begins slowly, the patient is aware that they are losing memory
 We know what causes it but don’t know why
 Discovered in 2014 a way to identify the beta amyloid in the blood system by 2020
 Cannot cure alzheimer’s disease, can only slow it down
 Ach deficiency also tend to see in movement disorders
 Concerns:
o Safety- losing the ability to perform ADLs, want to maintain the same caregiver,
moving them out of their regular environment might make them worse
 NMDA Receptor Blockers
o Different formulations
o Prevents glutamine from binding to cause from excitatory action
o If too low can impair memory and cognition
o Prevents the destruction of the neurons
o Would not give to someone who is in renal failure
o Cannot see plaques on a CT scan or an MRI
o Once a day
o Decrease in appetite, losing weight
o Sometimes taken with another drug
o Need to teach patient and caregivers that these medicines are not curative
o Will not give back what they already los
o Can come in patch, nice because they don’t have to remember to take everyday
 Reversible Cholinesterase Inhibitor
o The most commonly prescribed
o First anti-alzhiermer’s drug
o Only PO
o Look at their electrolytes- especially potassium
o Can have abnormal dreams, can wake up and then fall
Pharmacotherapy of Seizures
 Not a single disease
 Broad spectrum of nervous system disorders- i.e. brain tumors, electrolyte imbalances
(sodium)
 The word seizure is the actual electrical over firing on an EEG, a convulsion is the physical
manifestation of the over firing of the neuronal cell
 Also medication induced, febrile seizures in children
 Different types of seizures
 We need to block the sodium channels and potentiation of GABA, and blocking calcium
channels, and blocking glutamate receptors
 Barbiturates
o Very narrow therapeutic index
o Anti-epileptic drugs- have serum levels monitored
o Long half life: 50-120 hours
o Used commonly in the pediatric population
o GABA- is the inhibitory neurotransmitter
o Monitor of lethargy- should get drug level, might be at the toxic range

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