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Summary Kumar and Clark's Clinical Medicine E-Book, ISBN: 9780702053047 Bachelor of Medicine and Surgery $7.55   Add to cart

Summary

Summary Kumar and Clark's Clinical Medicine E-Book, ISBN: 9780702053047 Bachelor of Medicine and Surgery

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summary of cirrhosis and liver disease

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  • November 2, 2021
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Cirrhosis/Chronic liver failure

 Definition: Cirrhosis is a condition caused by chronic damage to the liver. The liver is

undergoing fibrosis and have abnormal regenerating nodules.

 Cirrhosis is characterized by hepatic parenchymal necrosis and an inflammatory

response to the underlying cause. Subsequent hepatic repair mechanisms lead to

fibrosis and abnormal tissue architecture, which impair liver function

 Most commonly due to excessive alcohol consumption, non-alcoholic fatty liver

disease, or hepatitis C infection. Other causes may include inflammatory or metabolic

diseases, such as primary biliary cirrhosis or hemochromatosis.

Causes

Hepatotoxicity(Liver damage)

 Chronic alcohol ingestion

 Medications (e.g., acetaminophen, amiodarone, chemotherapy drugs such as

methotrexate)

 Industrial chemicals such as tetrachloromethane

Inflammation (hepatitis)

 Chronic viral hepatitis: hepatitis B, hepatitis D, and hepatitis C(common)

 Primary biliary cirrhosis

 Primary sclerosing cholangitis

Metabolic disorders

 Non-alcoholic steatohepatitis (NASH)

 Hemochromatosis

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