Detailed, neat and organised lecture notes about the pathophysiology, risk factors, science and treatment behind vascular calcification. Document includes diagrams to help aid with understanding.
VASCULAR CALCIFICTION
WHAT IS VASCULAR CALCIFICATION?
- Deposition of bone‐like material within the arteries
- Causes vascular stiffness and high blood pressure
- Most individuals age 60+ have calcium deposits within the arterial wall – ageing is a risk factor
- Increasingly recognised as a SERIOUS problem, in 1982 only 16 papers, today over 4000
, when we have VC a lot of proteins and hydroxyapatite (mineral found in bone) which are normally located
in the skeletal system tend to be inhibited in the vasculature, so you get an imbalance between inhibitors
of calcification within the vascular system.
These might coincide so you might get bone loss, and osteoporosis and this can lead to higher calcium and
phosphate environment which can then contribute to VC process
VC IS HIGHLY REGULATED
- Not a passive process- not just a build of calcium and phosphate: highly regulated process
- Deposition of bone‐like material and upregulation of bone‐associated proteins within the arteries-
detect using immunohistochemistry
- Involves alteration in gene regulation- bone related proteins
ATHERSCLEROSIS
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