Lung and renal physiology, acid-base balance and temperature 221 (FLG 221) summary of ALL lecture notes
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Course
FLG 221 (FLG221)
Institution
University Of Pretoria (UP)
Book
Human Physiology
These extensive notes are based on the FLG 221 lecture notes and Human Physiology: an Integrated Approach textbook. The notes cover all the work in the module and have also been double checked using the learning outcomes in the study guide to ensure all the information was there. They also include ...
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FLG 221 (FLG221)
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Content preview
Renal physiology I
Urinary functions and functional anatomy
Urinary functions
• Aim: homeostasis in body fluids
• Regulation of ECF volume, osmolarity and electrolyte balance by handling water and
electrolytes
• Regulation of acid-base balance by controlling H+ and HCO3- levels
• Excretion of metabolic end-products and foreign substances like urea, uric acid and
creatinine
• Retaining of adequate amounts of essential substances
,
,Blood supply of the superficial and juxtamedullary nephrons
The renal corpuscle (body of Malphigi)
Mesangial cells
• Structural support for
capillaries
• Secrete extracellular
matrix
• Phagocytic activity
• Left: micrograph
showing podocyte foot
, processes around glomerular capillaries
• Right: fenestrations (small holes ±700 Å) of endothelial cells from inside of glomerular
capillary
Mechanisms of kidney function
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