PK BUNDLED Exams 2023 with 100% correct answers

Pharmacodynamics what the drug does to the body Pharmacokinetics what body does to the drug 2D6 SUBSTRATES SPARTEINE & BUFURALOL 2D6 INHIBITORS QUINIDINE 2D6 INDUCERS NK 2C8 SUBSTRATES PACLITAXEL & REPAGLINIDE 2C8 INHIBITORS MONTEKULAST (SINGULAIR) ...

Start of clearance concepts ** Elimination/Clearance of a drugs is primarily mediated through what 2 things? Metabolism and excretion ** Clearance (CL) can be used to describe the process of drug elimination from the body (as an alternative to the word elimination). also represent...

Which one of the following is the best definition of Clearance? a. Non-reversible removal of active drug from the systemic circulation b. Pre-systemic loss of active drug c. Steady target plasma concentration range d. Conversion of the administered drug into active drug A When a dr...

____________ is the physiological effect of the drug on the body. - Efficacy - Toxicity Pharmacodynamics ____________ = minimum concentration required for the drug to be effective in 50% of the population Minimum effective concentration ____________ - minimum concentration requir...

T/F Drug transfer is typically reversible or passive in transfer. True! Drug distribution refers to reversible transfer of drug between blood and extra vascular fluids and tissue of the body The extent and rate of distribution is dependent upon the ______ characteristics of the ____...

Which of the following exert an influence on the relationship between dose of a drug and the response. (Select all that apply) 1. Route of drug administration 2. Drug distribution to other parts of the body 3. Drug elimination from the body 4. Number and quality of receptors at the drug's site ...

A patient was admitted to the hospital because of acute myocardial infarction. After stabilizing his condition, the patient was given an IV loading dose of 150 mg of lidocaine followed by a constant rate IV infusion of 2 mg/min. What is the rate of lidocaine elimination at the steady-state? 2 mg/...

in the ANOVA analysis, the number of degrees of freedom between treatment groups equals k-1 the number of degrees of freedom within treatment groups equals N-k the plot of the logarithmic function ln x vs. the argument x is increasing the derivative of y with respect to t (dy...

B The Dad is JJ and does not have diabetes and Mom is JR and has diabetes: What inheritance pattern is exhibited? a) dominant b) recessive dominant c) co-dominant d) incomplete dominant A A patient comes to your clinic and her and her husband are expecting a baby. The father and mother...

T/F: a decrease in drug dose will result in lower plasma concentration(s) at steady state but will NOT change the time to reach steady state true depends on HALF-LIFE and not dose when drug clearance decreases(while Vd remains unchanged), steady-state plasma concentrations will do what? in...

Biopharmaceutics considers interrelationships of -physiochemical properties of drug -dosage form -route of administration Pharmacokinetics -what the body does to the drug -science of kinetics of drug absorption; distribution and elimination and corresponding pharmacological, the toxicol...