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Rafi Haematology: Questions With Complete Solutions
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Rafi Haematology: Questions With Complete Solutions
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Rafi Haematology: Questions With Complete SolutionsWhich one of the following answers corresponds with where haemopoesis is
primarily situated in a fetus at 3 months gestation?
Marrow of all bone
Liver and spleen
Fetal yolksac
Marrow of axial skeleton
Lymph nodes Right Ans - Liver and Spleen
"
Lymphoid progenitor cells travel to which organ to become T lymphocytes
Spleen
Liver
Thymus
Kidney
Thryoid Right Ans - Thymus
"
A 65 year old patient recieving chemo for disseminated malignancy attends
hospital with signs of an infection. A full blood count reveals that he has a
neutrophil count of < 0.1 109/L (normal range 2.0- 7.5 109/L). Which
haemopoietic growth factor would help improve his neutrophil count?
a. G-CSF.
b. EPO.
c. Romiplostim.
d. Eltrombopag.
e. Stem cell factor Right Ans - a. G-CSF
"
A patient suffering with idiopathic thrombocytopenic purpura undergoes a
splenectomy. She is advised to get the pneumococcal vaccine booster every
5-10 years. Which of the following properties of Strep. pneumoniae make her
prone to infection by this organism?
a. It is gram positive.
,b. It is a-haemolytic.
c. It is encapsulated.
d. It causes pneumonia.
e. It is a diplococcus Right Ans - c. It is encapsulated
"
Concerning bone marrow in the adult, which one of
the following is correct?
a. It is the only tissue in the body capable of
haemopoiesis .
b. Yellow marrow is where haemopoiesis normally
takes place.
c. It contains neutrophils which store iron for the
developing erythrocyte.
d. Red marrow is normally restricted to the axial
skeleton and the proximal ends of long bones.
e. It contains red and yellow marrow, as well as red
and white pulps Right Ans - "d. Red marrow is normally restricted to the
axial
skeleton and the proximal ends of long bones."
"
Regarding erythrocytes, which one of the following is correct?
a. They have a bilobed nucleus.
b. They are derived from lymphoid progenitor cells.
c. They transport CO2.
d. They have an average lifespan of 12 days.
e. They have a spherical shape. Right Ans - c. They transport CO2
"
Concerning iron metabolism, which one of the following is correct?
a. Iron is absorbed in the stomach.
b. Excess iron is readily excreted.
c. Iron is transported in the blood bound to apoferritin.
d. Primary haemochromatosis is caused by excessive iron absorption.
,e. Total body stores of iron are 4 mg. Right Ans - d. Primary
haemochromatosis is caused by excessive iron absorption.
"
Concerning haemoglobin, which one of the following is correct?
a. Adult haemoglobin contains 4 identical globin
chains.
b. Each haemoglobin can carry 4 molecules of oxygen.
c. Oxygen binding follows a hyperbolic curve.
d. 2,3-diphosphoglycerate levels rise in hypoxia to
allow increased oxygen uptake by haemoglobin.
e. The Bohr effect (a shift of the oxygen dissociation curve to the right) is due
to decreased H+ concentration. Right Ans - b. Each haemoglobin can carry
4 molecules of oxygen
"
Concerning fetal haemoglobin, which one of the following is correct?
a. It may be raised in b-thalassaemia syndromes.
b. It is composed of two a- and two b-globin chains.
c. It has a lower affinity for oxygen than adult haemoglobin.
d. It remains the primary haemoglobin in infants untilapproximately 2 years
of age.
e. It is normally about 2% of the haemoglobin in
adults. Right Ans - a. It may be raised in b-thalassaemia syndromes
"
Regarding haem production and metabolism, which one of the following is
correct?
a. Haem is produced in mitochondria in the liver.
b. Haem is broken down by macrophages in the gut.
c. Haem consists of four Fe2+ ions and a protoporphyrin ring.
d. Conjugated bilirubin is secreted into lymph.
e. Unconjugated bilirubin is water insoluble. Right Ans - e. Unconjugated
bilirubin is water insoluble.
Right Ans -
, Concerning erythropoietin (EPO), which one of the following is correct?
a. It is a steroid hormone.
b. It is mainly secreted by the Kupffer cells and hepatocytes in the liver.
c. The major stimulus for secretion is higher androgen levels.
d. Blood levels of EPO are raised at higher altitudes.
e. Splenectomy reduces levels of EPO, resulting in
anaemia. Right Ans - d. Blood levels of EPO are raised at higher altituides
"
Concerning vitamin B12, which one of the following is correct?
a. It is absorbed in the proximal jejunum.
b. It requires extrinsic factor for absorption.
c. It can also be synthesized by the skin.
d. It is stored in the bone marrow.
e. Total gastrectomy reduces absorption. Right Ans - e. total gastrectomy
reduces absorption
"
Regarding folic acid, which one of the following is correct?
a. Pernicious anaemia is a common cause of folic acid deficiency.
b. It is exclusively found in animal products.
c. It is utilized in the metabolism of alcohol.
d. It is absorbed in the stomach.
e. Folic acid deficiency requires an injection every
3 months. Right Ans - c. it is utilized in the metabolism of alcohol
"
A norchromic, normocytic anaemia is most commonly associated with which
one of the following?
a. Iron deficiency.
b. Renal failure.
c. Pernicious anaemia.
d. Thalassaemia.
e. Hereditary spherocytosis. Right Ans - "b. Renal failure
(anaemia of chronic disease)"
"
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