Pharmicodynamics
What the body does to a drug
What is the advantage to expressing drug dose as a log?
-we can go from 0.01 ug to 100 ug in one graph
-it allows us to express drug doses across a very wide range
-it expands the concentration at the lower axis - our ability to look at the bod...
Rush - Advanced Pharmacology - NSG
531 - Exam 1 Questions and Correct
Answers the Latest Update
Pharmicodynamics
✓ What the body does to a drug
What is the advantage to expressing drug dose as a log?
✓ -we can go from 0.01 ug to 100 ug in one graph
✓ -it allows us to express drug doses across a very wide range
✓ -it expands the concentration at the lower axis - our ability to look at the body's
response at the lower doses - because all of the action is happening at the left side of
the graph we want to be able to finely grade the graph on the side of the graph
where the response is happening
✓ -ability to compare graphs for different drugs - overlay
What do the three areas of an LDR curve represent?
✓ -it begins as flat where there is no difference from one integer to the next - no
response at this dose
✓ -the area where it rises is called the linear part of the graph - this is where we start
seeing effects by increasing the dose
✓ -the next part is called the plateau because increasing the dose gives no further
effects
graded response
✓ when we express the response on the y axis as an absolute value
✓ -numbers that can assume values across a scale
✓ -when the response is expressed on the y axis as whether or not the person is a
responder
✓ -expressed as % of people that respond or don't respond
what is an example of a response expressed as a percentage that is not a quantal
response?
✓ A1C - expressed as a percentage - measurable as a graded value on the y axis
On an LDR curve where Drug B falls to the right of Drug A, Which drug is more
potent?
✓ Drug A
What does it mean if one drug is more potent than another?
✓ You need less of that drug than the other drug to achieve the same effect
ED50
✓ the dose that produces a response equal to half of the maximum response
Efficacy
✓ the maximum response that a drug is capable of achieving
✓ (this is where the drug plateaus on the curve
What is an example of when it would be bad to get to the top of the maximum
dose?
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