Psoriasis def - Answer-Inflammatory disease which potentially affects the skin nails and joints. Between 2-3% of the population will have psoriasis: 7 mil in US
What is happening in the skin in psoriasis? - Answer-Skin cell turnover is greatly accelerated and shedding is occurring at a lower rat...
Psoriasis Exam Questions with Latest
Update
Psoriasis def - Answer-Inflammatory disease which potentially affects the skin nails and
joints. Between 2-3% of the population will have psoriasis: 7 mil in US
What is happening in the skin in psoriasis? - Answer-Skin cell turnover is greatly
accelerated and shedding is occurring at a lower rate than production
How long do normal skin cells take to become the outer epidermis? - Answer-28 days
What is the healthy (normal) skin cell life cycle of the epidermis? - Answer-1. Born
2. Become strong/pliable
3. Acquire normal size and thickness
4. Appropriately absorb/retain lipids and moisture
5. Shed in a timely manner
What might be the timeline for psoriatic skin cells? - Answer-7 days
What happens in the short time of psoriatic cells? - Answer-1. Born
2. Fail to become strong and flexible
3. Do not reach the correct size and thickness
4. Unable to absorb and maintain lipids and moisture, making them crack and dry, scaly
5. Do not shed in a timely manner meaning they stick to the epidermis
What biological triggers the increased skin cell turnover in psoriasis? - Answer--
Psoriasis is an auto immune disease. They have elevated levels if immune system
inflammatory mediators called cytokines
Most common cytokines of immune system - Answer-Tumor Necrosis Factor (TNF)
Interleukins
usually are only present during infectious or cancer. These cause the increased cell
turnover in psoriasis
What triggers the autoimmune responds in patients? - Answer--Genetics: set the stage
for psoriasis to occur
-Environmental factor: stress, smoking, drinking, diet will combine with genetics to
cause psoriasis to manifest
Which genes predispose one to psoriasis? - Answer-Still the focus of ongoing research.
What are some of the known environmental triggers? - Answer-1. Medications
2. Trauma/Injury to the skin
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