What are characteristics of major depressive disorder or MDD? 9 - ✔Diagnostics need 5
or more of the following:
- SS occur more days than not in a 2 week period
- SS cause significant impairment in any realm of functioning
- Depressed mood
- Loss of interest
- Significant unintended ▲ in weight or appetite
- Significant ▲ sleep
- ▲ psychomotor activity (restlessness)
- Fatigue, loss of energy
- Worthlessness, guilt
What is serotonin syndrome? - ✔- Increased serotonergic activity in the
CNS - Can be due to therapeutic med use, inadvertent drug interactions, or
self-OD
Serotonin in the Body:
CNS: Modulates attention, behavior, and thermoregulation
PNS: Regulates GI motility, vasoconstriction, uterine contraction, and bronchoconstriction,
promotes PLT aggregation
CONTRA - ✔MOA
- act to inhibit reuptake of NE, dopamine, and serotonin
, BENFIT
- Depression
- Smoking cessation
- Seasonal affective disorder
- Treat sexual dysfunction relative to SSRI therapy
AE
- weight loss
- increases libido ⇒ combine with SSRI
- can cause seizures by lowering the seizure threshold
CONTRA
- History of seizures
- Do not prescribe to pts with psych disorders ⇒ ↑ risk for delusions or hallucinations
RF for ETOH abuse 4 - ✔Younger adults (18-29 yrs)
Men > women
Native americans
Genetics (low response to ETOH), environment (peer influences), specific personality
traits (impulsivity, extroversion), cognitive fxn
What are predisposing factors impacting the likelihood of someone developing a SA issue? -
✔Predisposing Factors:
- Unhealthy use of one substance increases the likelihood of unhealthy use of other substances
- Family history
- Social history
- Partner or friends with SA, living in a community with poverty, violence, and/or
high ETOH/drug use
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