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PCB 3233: Immunology; Exam 2-Chapters 3 & 4 fully solved $12.99   Add to cart

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PCB 3233: Immunology; Exam 2-Chapters 3 & 4 fully solved

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PCB 3233: Immunology; Exam 2-Chapters 3 & 4 fully solved

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  • October 9, 2024
  • 9
  • 2024/2025
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PCB 3233: Immunology; Exam 2-
Chapters 3 & 4

When a mannose receptor is engaged what mechanism is initiated in a phagocyte? - correct answer
✔✔lectin complement



When CR3 & CR4 receptors are engaged what mechanism is initiated in a phagocyte? - correct answer
✔✔iC3b; LPS



When scavenger receptors are engaged what mechanism is initiated in a phagocyte? - correct answer
✔✔negatively charged molecules: nucleic acids, LPS, lipoteichoic acids



When the following TLRs are engaged what mechanism is initiated in a macrophage? - correct answer
✔✔cytokine creation and secretion



What does TLR-3 bind to? - correct answer ✔✔double-stranded viral RNA



What does TLR-4 bind to? - correct answer ✔✔gram-negative bacteria: LPS



What does TLR-5 bind to? - correct answer ✔✔bacteria falgellin



What does TLR-7 bind to? - correct answer ✔✔single-stranded viral RNA



TLR Signaling Mechanism - correct answer ✔✔1. a complex of TLR-4, MD2, CD14, and LPS assembles on
a macrophage surface

2. MyD88 binds to TLR4; IRAK4 binds to TRAF6, phosphorylates IKK

3. IKK phosphorylates IkB, releases NFkB

4. NFkB activates inflammatory cytokines

, What 5 genes are transcribed because of TLR-4 recognition? - correct answer ✔✔IL-1β, TNF-α, IL-6,
CXCL-8 (IL-8), IL-12



What is the general term given to the 5 gene products that are transcribed because of TLR-4
recognition? - correct answer ✔✔inflammatory cytokines



What do neutrophils do? - correct answer ✔✔phagocytosis



What is the lineage of neutrophils? - correct answer ✔✔hematopoietic stem cell-common myeloid
precursor-granulocyte macrophage progenitor-neutrophil



What is another name for neutrophils? - correct answer ✔✔polymorphonuclear leukocyte



What are the 4 classes of adhesion molecules? - correct answer ✔✔selectins, vascular addressins,
intergrins, immunoglobulin superfamily



What do selectins bind to? - correct answer ✔✔carbohydrates



What do vascular addressins bind to? - correct answer ✔✔L-selectins



What do integrins bind to? - correct answer ✔✔ICAM-1 (ig superfamily)



What does immunoglobulin superfamily bind to? - correct answer ✔✔LAF-1 (integrin)



What are the 4 steps of extravasation? - correct answer ✔✔1. rolling adhesion

2. tight binding

3. diapedesis

4. migration

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