Exam (elaborations)
Pathoma Exam: Questions With Solutions (Graded A+)
- Course
- Institution
Pathoma Exam: Questions With Solutions (Graded A+)
[Show more]
Content preview
Pathoma Exam: Questions With Solutions (Graded A+)DiGeorge Syndrome Right Ans - Developmental failure of the 3rd and 4th
pharyngeal pouches
Severe Combined Immunodeficiency (SCID) Right Ans - Defective cell-
mediated and humoral immunity
X-Linked Agammaglobulinemia Right Ans - Complete lack of
immunoglobulin due to disordered B-cell maturation
Common Variable Immunodeficiency (CVID) Right Ans - Low
immunoglobulin due to B-cell or helper T-cell defects
IgA Deficiency Right Ans - Low serum and mucosal IgA
Hyper-IgM Syndrome Right Ans - Characterized by elevated IgM
Wiskott-Aldrich Syndrome Right Ans - Characterized by
thrombocytopenia, eczema, and recurrent infections (defective humoral and
cellular immunity)
Systemic Lupus Erythematosus (SLE) Right Ans - Systemic autoimmune
disease
Sjogren Syndrome Right Ans - Autoimmune destruction of lacrimal and
salivary glands
Scleroderma Right Ans - Autoimmune tissue damage with activation of
fibroblasts and deposition of collagen (fibrosis)
Mixed Connective Tissue Disease Right Ans - Autoimmune-mediated tissue
damage with mixed features of SLE, systemic sclerosis, and polymyositis
Immune Thrombocytopenic Purpura (ITP) Right Ans - Autoimmune
production of IgG against platelet antigens
Microangiopathic Hemolytic Anemia Right Ans - Pathologic formation of
platelet microthrombi in small vessels
,Bernard-Soulier Syndrome Right Ans - Due to a genetic GPIb deficiency;
platelet adhesion is impaired
Glanzmann Thrombasthenia Right Ans - Due to a genetic GPIIb/IIIa
deficiency; platelet aggregation is impaired
Hemophilia A Right Ans - Genetic factor VIII deficiency
Hemophilia B (Christmas Disease) Right Ans - Genetic factor IX deficiency
Coagulation Factor Inhibitor Right Ans - Acquired antibody against a
coagulation factor resulting in impaired factor function
Von Willebrand Disease Right Ans - Genetic vWF deficiency
Heparin-Induced Thrombocytopenia Right Ans - Platelet destruction that
arises secondary to heparin therapy
Disseminated Intravascular Coagulation (DIC) Right Ans - Pathologic
activation of the coagulation cascade
Anemia Right Ans - Disruption in circulating red blood cell (RBC) mass
Anemia of Chronic Disease Right Ans - Anemia associated with chronic
inflammation or cancer
Iron Deficiency Anemia Right Ans - Anemia due to decreased levels of iron
Sideroblastic Anemia Right Ans - Anemia due to defective protoporphyrin
synthesis
Thalassemia Right Ans - Anemia due to decreased synthesis of the globin
chains of hemoglobin
Megaloblastic Anemia Right Ans - Anemia due to folate or vitamin B12
deficiency
, Hereditary Spherocytosis Right Ans - Inherited defect of RBC cytoskeleton-
membrane tethering proteins
Sickle Cell Anemia Right Ans - Autosomal recessive mutation in beta chain
of hemoglobin; a single amino acid change replaces normal glutamic acid
(hydrophilic) with valine (hydrophobic)
Paroxysmal Nocturnal Hemoglobinuria (PNH) Right Ans - Acquired defect
in myeloid stem cells resulting in absent glycosylphosphatidylinositol (GPI);
renders cells susceptible to destruction by complement
Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency Right Ans - X-
linked recessive disorder resulting in reduced half-life of G6PD; renders cells
susceptible to oxidative stress
Immune Hemolytic Anemia Right Ans - Antibody-mediated (IgG or IgM)
destruction of RBCs
Microangiopathic Hemolytic Anemia Right Ans - Intravascular hemolysis
that results from vascular pathology; RBCs are destroyed as they pass through
the circulation
Malaria Right Ans - Infection of RBCs and liver with Plasmodium;
transmitted by the female Anopheles mosquito
Parvovirus B19 Right Ans - Infects progenitor red cells and temporarily
halts erythropoiesis; leads to significant anemia in the setting of preexisting
marrow stress (e.g., sickle cell anemia)
Aplastic Anemia Right Ans - Damage to hematopoietic stem cells, resulting
in pancytopenia (anemia, thromobocytopenia, and leukopenia) with low
reticulocyte count
Infectious Mononucleosis Right Ans - EBV infection that results in a
lymphocytic leukocytosis comprised of reactive CD8+ T cells; CMV is a less
common cause
Acute Lymphoblastic Leukemia (ALL) Right Ans - Neoplastic accumulation
of lymphoblasts (>20%) in the bone marrow
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller LeCrae. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $23.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
72042 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now