Lithium toxicity level greater than or equal to 1.5
what is the gold standard for treating manic Lithium
episodes?
What drug has evidence of anti-suicidal Lithium
effects for bipolar disorder?
TSH (r/o bipolar)
Creatinine (0.6-1.2)
baseline labs to collect in order to R/O
BUN (10-20)
medical diagnoses prior to giving Lithium
Pregnancy test
ECG if greater than 50 (inverted T-waves)
All psychotropics should have what test pregnancy test
prior to giving for child-bearing age?
what is considered child-bearing age? 12-51
SE of Lithium? (endocrine) HYPOthyroidism
SE of Lithium? (CNS) **course hand tremors w/ toxicity
SE of Lithium? (dermatological) Maculopapular rash
diarrhea, vomiting, cramp, anorexia
SE of Lithium? (GI)
**imp. because these become severe w/ toxicity
SE of Lithium? (Renal) diabetes insipidus (polyuria r/t polydipsia)
SE of Lithium? (Cardiac) T-wave inversions
SE of Lithium? (Hematologic) leukocytosis (increased WBC)
MAOIs are taken in conjunction w/ foods containing TYRAMINE (dietary precursor of
Hypertensive Crisis occurs when.....
NE)
Hypertensive crisis is __________ and life-threatening & cannot be reversed unless more MAO is produced by the body
cannot be reversed unless.....
Hypertensive crisis & death can occur ***Meperidine
when MAOIs are taken in conjunction with ***Stimulants/other sympathomimetics
which types of meds?? Decongestants/TCA/SGA/St. Johns Wort/L-tryptophan
sudden explosive-like HA in OCCIPITAL region
Symptoms of Hypertensive crisis include
Fever**
1/7
, 10/4/24, 6:01 PM
1. d/c offending agent (MAOI)
Treatment of Hypertensive Crisis 2. administer PHENTOLAMINE
3. Stabilize fever
medication to reverse hypertensive crisis Phentolamine****
w/ MAOI?
Isocarboxazid (Marplan)
List of common MAOIs (don't need to Phenelzine (Nardil)
memorize, just know what it looks like) Selegiline (Emsam)
Tranylcypromine (Parnate)
Steven Johnson's Syndrome*** (SE below, KNOW)
- Fever**
- Sore throat (may feel like burning**
Lamicatal main SE - Facial/tongue swelling**
- Skin sloughing***
- Prodromal HA, malaise, Arthralgia, painful mucous membranes may occur BEFORE
rash
Valproic Acid/Divalproex Sodium aka Hepatotoxicity**
Depakote main SE Pancreatitis**
Agranulocytosis***
Carbamazepine (Tegretol) main SE Aplastic Anemia***
Steven-Johnson's*** (mainly Asians HLAB-1502 allele)
Aplastic Anemia s/s pallor, fatigue, HA, fever, nose bleeds, bleeding gums, skin rash, SOB
WBC 2000-3000
ANC < 1000
Carbamazepine when to d/c
Rash/Steven Johnson's
Or s/s of aplastic anemia or agranulocytosis
What to test prior to prescribing HLA-B 1502 allele in Asians d/t Steven's Johnson Syndrome
Cabamazepine??
Clozapine main SE Risk for NEUTROPENIA --> monitor for s/s of infection***
Neutropenia is monitored only by... ANC
ANC <1000
when to d/c Clozapine?
WBC 2000-3000
Check___ before starting female of HCG
childbearing age (12-51yr) on psychotropic
med
supports neural tube development during FIRST month of pregnancy--> ALWAYS
Folic acid does what & what is the
encourage those of childbearing age to take (OTC medication)
recommended dosage?
Dosage= 0.4-0.8mg daily for all women planning or capable of becoming pregnant**
Fever
Sore throat (burning feeling)
Symptoms of Steven's Johnson Syndrome Facial/Tongue Swelling
Rash
Skin Sloughing
2/7
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