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NBME Practice MCB Questions And Answers
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NBME Practice MCB Questions AndAnswers
A 2 year old girl who is exposed to the sun has progressive
development of dryness of the skin, excessive freckling, and
keratoses. Skin fibroblasts cultured from this child are most likely to
be defective in which of the following? - - correct answer
✅Nuclear excision repair of pyrimidine dimers
a 65 year old man has a radical prostacetomy and lymph node
dissection for adenocarcinoma of the prostate. which of the
following features is involved in the grading of this neoplasm - -
correct answer ✅Tumor size
A man with a fair complexion develops an ulcerated nodule on his
face after prolonged exposure to sunlight. Examination of tissue
obtained on excision of the nodule shows invasive squamous cell
carcinoma. Which of the following types of DNA damage is most
likely responsible for this leason? - - correct answer ✅Pyrimidine
dimers
A 45 year old woman with cancer is undergoing an intensive 2 week
course of chemotherapy with vinblastine. Which of the following
changes is most likely to occur by the end of this treatment? - -
correct answer ✅Decreased number of neutrophils - vinblastin
mechanism is to bind microtubular proteins in the mitotic spindle,
thereby preventing cell division during metaphase. (anaphase
promoting complex inhibitor)
,NBME Practice MCB Questions And
Answers
An 11 year old boy has had pain in his right mid thigh for 2 weeks.
Physical examination shows an area of warmth and tenderness
around an ill defined mass. X ray of the femure shows a solitary mid
diaphyseal osteolytic lesion with permeative margins. The lesion is
surrounded by concentric layers of reactive bone. Tissue obtained
on biosy of the mass is composed of poorly differentiated sheets of
small, uniform, hyperchromatic cells with a very high nuclear
cytoplasmic ratio, scant stroma, and no visible matrix. Which of the
following is the most likely diagnosis? - - correct answer ✅Ewing
sarcoma - Ewing sarcoma is a type of cancer that may be a bone
sarcoma or a soft-tissue sarcoma. Symptoms may include swelling
and pain at the site of the tumor, fever, and a bone fracture.
a 55 year old woman with colon cancer and a healthy 55 year old
woman are participating in a study of colon cancer. malignant cells
are obtained from the tumor in the affect patient, and normal
colonic epithelial cells are procured from the healthy subject. After
both cell tpyes are treated with transforming growth factor B, the
number of normal cells decreases whereas the number of tumor
cells remains unchanged. The tumor cells most likely express a
mutation that inhibits which of the following physiological
processes. - - correct answer ✅Apoptosis
,NBME Practice MCB Questions And
Answers
A 10 month old boy has an abdominal mass noted during a routine
physical examination. Abdominal ultrasonography shows a 10 cm
solid mass on the upper pole of the left kidney. Angiographically,
the mass is hypervascular. Which of the following is the most likely
diagnosis? - - correct answer ✅Nephroblastoma (Wilms Tumor)
A 52 year old man comes to the physician because of a 3 month
hisotry of epigastric abdominal painl; he used to live in japan, is a
smokr and drinks three to four glasses of wine daily. Physical exam
shows epigastric tenderness. Upper gastrointestinal endoscopy
shows a 4 cm ulcer in the stomach. Examination of a biosy
specimen of the lesion confirms adenocarinoma. Which of the
following is the strongest predisposing risk factor for the patient's
condition? - - correct answer ✅Diet
An investigator conducts a study of the molecular basis of von
Hippel lindau disease, specifically the role of the VHL protein in the
disease process. The protein forms part of a ubiquitin ligase
complex (E3) that targets hypoxia- inducible factor -1. The pathway
is shown in the diagram. Step IV most likely involves which of the
following organelles? - - correct answer ✅Proteasome
A 28 year old man is diagnosed with advanced testicular cancer.
Combination chemotherapy is being considered. Cisplatin is
, NBME Practice MCB Questions And
Answers
included in the regimen because of its effect on which of the
following? - - correct answer ✅DNA
A study is conducted of breast cancer cell invasion of surrounding
tissues and metastasis. Two breast cancer cell lines, in the presence
and absence of macrophages are analyzed. The macrophages are
found to secrete a protein that is essential for invasion and
metastasis. This protein is most likely which of the following? - -
correct answer ✅Metalloproteinases (MMPS)
An investigator is studying the effect of paclitaxel on the growth of
breast cancer cells. The investigator observes that the drug binds to
microtubules. This binding will interfere with the completion of
which of the following stages of the cell cycle? - - correct answer
✅M phase
A 3 year old boy is brought to the physician because of episodes of
sunburn after brief sun exposure during the past 18 months.
Typically, the sunburn persisted for more than 2 weeks. A 12 year
old cousin has basal cell carinoma. Physical examination shows
numerous freckles and erythamatous, scaly, rough macules in sun
exposed areas. Anaylsis of cultered skin fibroblasts shows a tenfold
increased sensitivity to ultraviolet radiation compared with
standard human fibroblasts. which of the following DNA lesions is
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