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Valproic Acid Questions and Answers
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Valproic Acid Questions and Answers 1. Moa (MECHANISM OF ACTION) a. Causes increased availability of GABA to enhance action of GABA 2. What is the therapeutic category? a. Anticonvulsant Previous Play Next Rewind 10 seconds Move forward 10 seconds Unmute 0:00 / 0:15 Full...

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  • September 28, 2024
  • 3
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • valproic acid questions and answers
  • 1 moa mechanism of action a causes increased a
  • 2 what is the therapeutic category a anticonvul

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  • ASID
  • ASID

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Valproic Acid Questions and Answers
1. Moa (MECHANISM OF ACTION) - answer a. Causes increased availability of
GABA to enhance action of GABA

2. What is the therapeutic category? - answer a. Anticonvulsant

3. For what indications (when it would be used) would Valproic Acid be utilized? -
answer a. Treatment of patients with complex partial seizures

4. Precautions (WARNINGS AND PRECAUTIONS; CONTRAINDICATIONS)? - answer
a. Hepatic failure [US BOXED WARNING]: hepatic failure has occurred within 6 months
of initial therapy
b. Pancreatitis: can cause life-threatening pancreatitis occurring at start of therapy or
following years of use
c. Brain atrophy: motor and cognitive function should be routinely monitored
d. Hypothermia:
e. Hyperammonemia/encephalopathy: Ammonia levels should be measured when
patients develop unexplained lethargy and vomiting

5. Adverse Reactions? - answer a. Headache
b. Drowsiness
c. Dizziness
d. Insomnia
e. Alopecia
f. N and V
g. Tremors

6. Potential drug-drug interactions, drug-food interactions (DRUG/ FOOD
INTERACTIONS)? - answer a. Food may delay but does not affect extent of
absorption
b. Contraceptives (Estrogens): may decrease concentration of valproate products
c. Lorazepam: valproate products may increase concentration of lorazepam

7. How is the drug excreted (PHARMACODYNAMICS)? - answer a. Urine - 30 to 50
percent as glucuronide conjugate
b. Faster clearance occurs in children receiving other antiepileptic drugs and those who
are younger

8. Are there any monitoring issues related to patients in renal failure or hepatic failure
(ADVERSE; DOSING; ADMINISTRATION; WARNINGS/PRECAUTIONS)? - answer
a. Adverse
i. Hepatic: increased serum ALT (1 to 5 percent)

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