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Valproic Acid Questions and Answers
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Valproic Acid Questions and Answers Generic name: Valproic Acid Trade name: Depakote Classification Antiepileptic 0:06 / 0:30 FDA Category D, X Pharmacologic The drug undergoes extensive hepatic metabolism followed by renal excretion.Valproic acid is readily absorbed ...

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  • September 28, 2024
  • 2
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • valproic acid questions and answers
  • generic name valproic acid trade name depakote
  • classification antiepileptic

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Valproic Acid Questions and Answers
Generic name: Valproic Acid - answer Trade name: Depakote

Classification - answer Antiepileptic

FDA Category - answer D, X

Pharmacologic - answer The drug undergoes extensive hepatic metabolism followed
by renal excretion.Valproic acid is readily absorbed from the GI tract and widely
distributed throughout the body.

Therapeutic - answer Seizure disorders: (Valproic Acid is considered a first line drug
for all partial and generalized seizures)
Bipolar disorder: (It can provide symptomatic control in pts with bipolar)
Migraine: (Approved for prophylaxis of migraine)
(Therapeutic responses are often seen at plasma levels of 40 to 100 mcg/ml. However,
the correlation between plasma levels and therapeutic effects is not very tight.)

Mechanism of action - answer Valproic acids appears to act by three mechanisms.
First, it shares the same mechanism as Phenytoin and carbamazepine: suppression of
high frequency neuronal firing through blockade of sodium channels. Second, it
suppresses calcium influx through T-type calcium channels. Third, it may augment the
inhibitory influence of GABA

Administration - answer Oral and IV

Dosage - answer Initially starts off low,
for adults and older children 5 to 15mg/kg/day administered in divided doses.
Maintenance dose is usually 0.75 to 3gm/day.
For children the initial dosage is 10 to 30 mg/kg/day administered in divided doses and
the usual maintenance dose is 15 to 45 mg/kg/day
IV dose is 100 mg/ml solution (depacon)

Side effects - answer Rash , weight gain, hair loss, tremor, blood dyscrasias.GI
effects are most common, N/V and indigestion . Hepatotoxicity and pancreatitis are rare
but serious. Highly teratogenic, especially in first trimester.

Drug interactions/Contraindications - answer Phenobarbital, Phenytoin, Topiramate,
Carbapenem Antibiotics, Alcohol, CNS depressants.

Nursing considerations - answer Taper when stopping,monitor cbc, lfts, therapeutic
serum level (usually 50 to 100 mcg/ml) not for use in pregnancy, watch for suicidal
thoughts and actions

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