A 2 year old girl who is exposed to the sun has progressive development of dryness of the skin, excessive freckling, and keratoses. Skin fibroblasts cultured from this child are most likely to be defective in which of the following?
Nuclear excision repair of pyrimidine dimers
a 65 year old m...
NBME Practice MCB Questions 1-200
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1. A 2 year old girl who is exposed to the sun has
Nuclear
progressive development of dryness of the skin, ex-
excision
cessive freckling, and keratoses. Skin fibroblasts
repair of
cul- tured from this child are most likely to be
pyrimi- dine
defective in which of the following?
dimers
2. a 65 year old man has a radical prostacetomy and
lymph node dissection for adenocarcinoma of the
prostate. which of the following features is
involved in the grading of this neoplasm Tumor size
3. A man with a fair complexion develops an ulcerated
nodule on his face after prolonged exposure to sun-
light. Examination of tissue obtained on excision of
the nodule shows invasive squamous cell Pyrimidine
carcinoma. Which of the following types of DNA dimers
damage is most likely responsible for this leason?
4. A 45 year old woman with cancer is undergoing an
in- tensive 2 week course of chemotherapy with
vinblas- tine. Which of the following changes is
most likely to occur by the end of this treatment?
Decreased
num- ber of
neutrophils
- vinblastin
mech- anism is
to bind
microtubular
pro- teins in
the mitot- ic
spindle, there-
5. An 11 year old boy has had pain in his right mid by preventing
thigh for 2 weeks. Physical examination shows an cell division
area of warmth and tenderness around an ill defined dur- ing
mass. X ray of the femure shows a solitary mid metaphase.
diaphyseal osteolytic lesion with permeative (anaphase
margins. The lesion is surrounded by concentric pro- moting
layers of reactive bone. Tissue obtained on biosy of complex
the mass is composed of inhibitor)
1/
, NBME Practice MCB Questions 1-200
Study online at https://quizlet.com/_9oqgmq
Ewing sarcoma - Ewing sarcoma is a type of can-
cer that may be a bone sarcoma or a soft-tissue
sarcoma. Symp-
2/
, NBME Practice MCB Questions 1-200
Study online at https://quizlet.com/_9oqgmq
poorly differentiated sheets of small, uniform, role of the
hyper- chromatic cells with a very high nuclear VHL protein
cytoplasmic ratio, scant stroma, and no visible in the
matrix. Which of the following is the most likely disease
diagnosis? process. The
protein
forms part of
6. a 55 year old woman with colon cancer and a a ubiquitin
healthy 55 year old woman are participating in a ligase
study of colon cancer. malignant cells are obtained complex (E3)
from the tumor in the affect patient, and normal
colonic ep- ithelial cells are procured from the
healthy subject. After both cell tpyes are treated
with transforming growth factor B, the number of
normal cells decreas- es whereas the number of
tumor cells remains un- changed. The tumor cells
most likely express a muta- tion that inhibits which
of the following physiological processes.
7. A 10 month old boy has an abdominal mass noted
during a routine physical examination. Abdominal
ultrasonography shows a 10 cm solid mass on the
upper pole of the left kidney. Angiographically, the
mass is hypervascular. Which of the following is
the most likely diagnosis?
8. A 52 year old man comes to the physician
because of a 3 month hisotry of epigastric
abdominal painl; he used to live in japan, is a
smokr and drinks three to four glasses of wine
daily. Physical exam
shows epigastric tenderness. Upper
gastrointestinal endoscopy shows a 4 cm ulcer in
the stomach. Ex- amination of a biosy specimen of
the lesion con- firms adenocarinoma. Which of the
following is the strongest predisposing risk factor
for the patient's condition?
9. An investigator conducts a study of the molecular
basis of von Hippel lindau disease, specifically the
3/
, NBME Practice MCB Questions 1-200
Study online at https://quizlet.com/_9oqgmq
toms may include swelling and pain at the site of
the tumor, fever, and a bone fracture.
Apoptosis
Nephroblastoma (Wilms Tumor)
Diet
Proteasome
4/
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