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Basic and Applied Concepts of Blood
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Basic and Applied Concepts of Blood
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Basic and Applied Concepts of Blood
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TEST BANK FOR IMMUNOHEMATOL OGY 4TH EDITION BY HOWARD | VERIFIED 2023/2024
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TEST BANK for Basic and Applied Concepts of Blood Bankingand Transfusion Practices 5th Edition By Howard
How would the hematocrit of a patient with chronic anemia be affected by the
transfusion of a unit of Whole Blood containing 475 mL of blood, vs 2 units of Red
Blood Cells each with a total volume of 250 mL?
a. patient's hematocrit would be equally affected by the Whole Blood or the Red
Blood cells
b. Red blood cells would provide twice the increment in hematocrit as the whole
blood
c. whole blood would provide twice the increment in hematocrit as the red blood
cells
d. whole blood would provide a change in hematocrit slightly less than the red blood
cells - ANSWER:b
Each unit of whole blood or rbcs will increase the hematocrit 3%-5%, so 2 units of
rbcs will increase the hematocrit by twice as must as 1 unit of whole blood
After checking the inventory, it was noted that there were no units on the shelf
marked "May issue as Uncrossmatched: For Emergency Only". Which of the
following should be placed on this shelf?
a. 1 unit of each of the ABO blood groups
b. units of group O, Rh-positive whole blood
c. units of group O, Rh-negative red blood cells
d. any units that are expiring at midnight - ANSWER:c
For emergency transfusions, group O-rbc units should be used.
The primary indication for granulocyte transfusion is:
a. prophylactic treatment for infection
b. additional supportive therapy in those patients who are responsive to antibiotic
therapy
c. clinical situations where bone marrow recovery is not anticipated
d. severe neutropenia with an infection that is nonresponsive to antibiotic therapy -
ANSWER:d
Granulocyte transfusions may be indicated for severely neutropenic patients with
infection not controlled by antibiotic therapy, who are expected to recover bone
marrow production of white cells.
A 42 yr old male of average body mass has a history of chronic anemia requiring
transfusion support. Two units of red blood cells are transfused. If the pretransfusion
,hemoglobin was 7.0 g/dl (70g/L), the expected posttransfusion hemoglobin
concentration should be:
a. 8.0 g/dl (80g/L)
b. 9.0 g/dl (90g/L)
c. 10.0 g/dl (100 g/L)
d. 11.0 g/dl (110 g/L) - ANSWER:b
Each unit of rbcs is expected to increase the hemoglobin level by 1-1.5 g/dl (10-15
g/L).
How many units of red blood cells are required to raise the hematocrit of a 70 kg
nonbleeding man from 24% to 30%?
a. 1
b. 2
c. 3
d. 4 - ANSWER:b
Each unit of rbcs is expected to increase the hematocrit level 3%-5%, so it would take
2 units to raise the level 6%.
For which of the following transfusion candidates would CMV-seronegative blood be
most likely indicated?
a. renal dialysis patients
b. sickle cell patient
c. bone marrow and hematopoietic cell transplant recipients
d. CMV-seropositive patients - ANSWER:c
CMV-seronegative or leukoreduced blood products should be administered to
immunocompromised patients, including bone marrow and hematopoietic cell
transplant recipients.
Although ABO compatibility is preferred, ABO incompatible product may be
administered when transfusing:
a. Single-Donor Plasma
b. Cryoprecipitated AHF
c. FFP
d. Granulocytes - ANSWER:b
Cryoprecipitate contains ABO antibodies so one should consider giving ABO
compatible, especially when infusing large volumes.
Transfusion of plateletpheresis products from HLA-compatible donors is the
preferred treatment:
, a. recently diagnosed cases of TTP with severe thrombocytopenia
b. acute leukemia in relapse with neutropenia, thrombocytopenia and sepsis
c. immune thrombocytopenic purpura
d. severely thrombocytopenic patients, known to be refractory to random donor
platelets - ANSWER:d
Class I HLA antigens on platelets are a known cause for platelet refractoriness.
Leukoreduction of blood products is used as a mechanism to reduce or prevent
patients from developing antibodies.
Washed red blood cells are indicated in which of the following situations?
a. an IgA-deficient patient with a history of transfusion-associated anaphylaxis
b. a pregnant woman with a history of hemolytic disease of the newborn
c. a patient with a positive DAT and red cell autoantibody
d. a newborn with a hematocrit of <30% - ANSWER:a
Patients with IgA deficiency who have had anaphylactic transfusion reactions should
receive washed rbcs. Anaphylactic reactions are typically caused by anti-IgA in the
recipient. Washing removes plasma IgA from the donor unit cells
Which of the following is consistent with standard blood bank procedure governing
the infusion of FFP?
a. only blood group-specific plasma may be administered
b. group O may be administered to recipients of all blood groups
c. group AB may be administered to AB recipients only
d. group A may be administered to both A and O recipients - ANSWER:d
FFP should be ABO compatible with the recipient's RBCs. Avoid FFP with antibodies
to A or B antigens the patient may have. Group A plasma has anti-B, and should only
be transfused to A or O recipients.
A patient who is group AB, Rh-negative needs 2 units of FFP. Which of the following
units of plasma would be most acceptable for transfusion?
a. group O, Rh-negative
b. group A, Rh-negative
c. group B, Rh-positive
d. group AB, Rh-positive - ANSWER:d
FFP should be ABO compatible with the recipient's RBCs. Avoid FFP with ABO
antibodies to A or B antigens the patient may have.
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