PMY 302 EXAM 1 DRUGS Study Guide
Diphenhydramine - answersuppress edema, pruritis and causes drowiness
Benadryl vs Advil PM
minodoxil - answertreat hypertension but topically used for hair growth
loniten vs rogaine
Examples of Type A ADRs - answersulbutamol- bronchi dilates in lungs at B2 but ...
warfarin and heparin - bleeding
alcohol and acetaminophen - increase CYP2E1 toxin
grapefruit - inhibits C450 which inc plasma drug conc
Example of pharmacogenetics on Type A ADRs - polymorphism of N-acetyl transferase (NAT) -
answer✔✔ADR on pharmacokinetics example : slow acetylators causes decrease in hepatic
elimination
Choline acetyl transferase - answer✔✔makes Ach
Phenylethanoamine N-methyltransferase - answer✔✔Make EPI from NE
commonality between somatic, PNS and SNS is: - answer✔✔first synapse uses Ach nicotinic
receptors
pilocarpine - answer✔✔Muscarinic agonist - used in open angled glaucoma - causes miosis in
the eye
echothiophate - answer✔✔AchE inhibitor used in open angled glaucoma
Ach IV : high vs low dose - answer✔✔high : will cause decrease in HR, BP and CO
low : will cause tachycardia - why?
At low dose, Ach has a higher affinity for M3 endothelial receptors. These cause an activation in
NO which will cause vasodilation thus decreasing BP. Then you will get a reflex to get
tachycardia
Bethanechol - answer✔✔pure muscarinic agonist , resistant to AchE because has a NH2+ group
carbachol - answer✔✔strong nicotinic agonist, resistant to AchE because has a NH2+ group.
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