Amphotericin B - ANSWER -polyene macrolide
-broad spectrum antifungal
*HIGHLY TOXIC*
-only given for infections that are progressive and potentially fatal
- given IV only
Amphotericin B Black Box Warning - ANSWER should only be used in the setting of a potentially life-threatening infectio...
-only given for infections that are progressive and potentially fatal
- given IV only
Amphotericin B Black Box Warning - ANSWER should only be used in the setting of a potentially life-
threatening infection
Amphotericin B side effects - ANSWER -infusion reactions (fever, chills,rigors, nausea, headache)
-neprhotoxic
-bone marrow suppression
Itraconazole (Sporanox) - ANSWER -alternative to amph b for systemic mycoses
- safer; oral dosing
- adverse effects cardiosupporession and liver injury
-causes transient decrease in EF
-administration with cola enhances absorption
Itraconazole Black Box Warning - ANSWER negative inotropic actions; should not be used for
superficial fungal infections, patients with HF, hx of HF or other indications of ventricular dysfunction
Drug interactions with Amphotericin B - ANSWER increased risk for kidney damage when used with
other nephrotoxic drugs such as:
aminoglycosides
cyclsoporine
, NSAIDs
Azoles for systemic mycoses - ANSWER itraconazole
ketoconazole
fluconazole
voriconazole
posaconazole
isavuconazonium
Drug interactios with Itraconazole - ANSWER -cyclosporine
-warfarin
-sulfonylurea-type oral hypoglycemics
-digoxin
-quinidine
-give antacids 1 hour before or 2 hours after
Prescribing Considerations for Azoles - ANSWER -use with caution in patients with liver disease
-avoid use with drugs metabolized by cyp3a4:
-warfarin
-cyclosporine
-digoxin
-quinidine
Lifespan considerations for Azoles - ANSWER ketoconazole has high potential for hepatotoxicity; do
not use in breastfeeding women
Treatment for tinea corporis (ringworm) - ANSWER Topical anti-fungal medication
Terbinafine
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