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Exam (elaborations)

BOC Immunology Training Exam Questions Solved Correctly.

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  • Course
  • Boc serology immunology
  • Institution
  • Boc Serology Immunology

b (lupus erythematosus) - Answer 1) Antinuclear antibody tests are performed to help diagnose? a) acute leukemia b) lupus erythematosus c) hemolytic anemia d) Crohn disease c (Crithida lucilia) - Answer 2. In the anti-double-stranded DNA procedure, the antigen most commonly utilized is...

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  • September 4, 2024
  • 59
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • Boc serology immunology
  • Boc serology immunology
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BOC Immunology Training Exam
Questions Solved Correctly.
b (lupus erythematosus) - Answer 1) Antinuclear antibody tests are performed to help diagnose?

a) acute leukemia

b) lupus erythematosus

c) hemolytic anemia

d) Crohn disease



c (Crithida lucilia) - Answer 2. In the anti-double-stranded DNA procedure, the antigen most commonly
utilized is:



a. rat stomach tissue

b. mouse kidney tissue

c. Crithida lucilia

d. Toxoplasma gondii



c (diagram C) - Answer 3) Which of the ANA patterns shown above would be associated with high titers
of antibodies to the Sm antigen?

a) diagram A

b) diagram B

c) diagram C

d) diagram D



b (5°C +/- 2°) - Answer 4) Sera to be tested for IFA-ANA 6 days after drawing is best stored at?

a) room temperature

b) 5°C +/- 2°

c) -70°C in a constant temperature freezer

,d) -20°C in a frost-free self-defrosting freezer



a (rim) - Answer 5) Antibodies directed at native DNA are most frequently associated with which
pattern of fluorescence in the IFA-ANA test?

a) rim

b) diffuse

c) speckled

d) centromere



b (expected for anti-DNA antibodies) - Answer 6) The technologist observes apparent homogenous
staining of the nucleus of interphase cells while performing an IFA-ANA, as well as staining of the
chromosomes in mitotic cells. This result is:

a) indicative of 2 antibodies, which should be separately reported after titration

b) expected for anti-DNA antibodies

c) inconsistent; the test should be reported with new reagent

d) expected for anti-centromere antibodies



a (anti-dsDNA titer 1:80, and a high titer of antibodies to Sm) - Answer 7) The result of an anti-nuclear
antibody test was a titer of 1:320 with a peripheral pattern. Which of the following sets of results best
correlate with these results?

a) anti-dsDNA titer 1:80, and a high titer of antibodies to Sm

b) antimitochondrial antibody titer 1:160, and antibodies to RNP

c) anti-Scl-70, and antibodies to single-stranded DNA

d) high titers of anti-SS-A and anti-SS-B



a (high titers of DNA antibody) - Answer 8) Systemic lupus erythematosus patients often have which of
the following test results?

a) high titers of DNA antibody

b) decreased serum immunoglobulin levels

c) high titers of anti-smooth muscle antibodies

d) high titers of antimitochondrial antibody

,c (marked decrease in serum CH50) - Answer 9. Systemic lupus erythematosus patients with active
disease often have which of the following test results?



a. high titers of antimicrosomal antibodies

b. high titers of anti-smooth muscle antibodies

c. marked decrease in serum CH50

d. decreased serum immunoglobulin levels



c (complement (C3)) - Answer 10. Which of the following is decreased in serum during the active stages
of systemic lupus erythematosus?



a. anti-nuclear antibody

b. immune complexes

c. complement (C3)

d. anti-DNA



c (CREST syndrome) - Answer 11. A positive ANA with the pattern of anticentromere antibodies is most
frequently seen in patients with:



a. rheumatoid arthritis

b. systemic lupus erythematosus

c. CREST syndrome

d. Sjӧgren syndrome



DNA - Answer 12. In the indirect fluorescent anti-nuclear antibody test, a homogenous pattern
indicates the presence of antibody to:



a. RNP

b. Sm

, c. RNA

d. DNA



b (Sm) - Answer 13. In the indirect fluorescent anti-nuclear antibody test, a speckled pattern may
indicate the presence of antibody to:



a. histone

b. Sm

c. RNA

d. DNA



c (lupus erythematosus) - Answer 14) A patient has the following test results:



The above results could be seen in patients with:

a) rheumatic fever

b) rheumatoid arthritis

c) lupus erythematosus

d) glomerulonephritis



a (mixed connective tissue disease) - Answer 15. Autoantibodies in the absence of Sm are found in
patients with:



a. mixed connective tissue disease

b. systemic lupus erythematosus

c. Crohn disease

d. multiple myeloma



a (nephelometry) - Answer 16) Which of the following is the most sensitive and appropriate method
for the detection of rheumatoid factor?

a) nephelometry

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