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ABSITE - Transfusion/Coagulation Questions and Answers
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Which of the following statements concerning von Willebrand factor is correct?  :-- It binds to specific platelet receptors. (von Willebrand factor binds to Glycoprotein Ib and IIb/IIIa receptors on the platelet, as well as to binding sites on the collagen in the subendothelium. ) Anticoagu...

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  • August 28, 2024
  • 16
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • absite transfusioncoagulation questions and ans

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Elscores: Aug. 27, 24- 2024/2025

ABSITE - Transfusion/Coagulation
Questions and Answers
Which of the following statements concerning von Willebrand factor is correct?


 :-- It binds to specific platelet receptors.

(von Willebrand factor binds to Glycoprotein Ib and IIb/IIIa receptors on the platelet, as well as

to binding sites on the collagen in the subendothelium. )




Anticoagulant response to coumarin-type drugs


 :-- Is caused by decreased levels of vitamin K-dependent factors.

(Coumarin interferes with vitamin K reductase and vitamin K epoxide reductase, two enzymes

that recycle vitamin K. This produces a vitamin K deficiency and impaired synthesis of vitamin

K-dependent factors.)




The leukocyte most directly implicated in the pathogenesis of ischemia-reperfusion injury is the


 :-- neutrophil




During stress, the liver output of ______ is increased up to eight-fold.


 :-- Fibrinogen.

(Fibrinogen and acute phase reactants are substantially increased in response to hemorrhage or

stress.)




Chronic disseminated intravascular coagulation



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, 2
Elscores: Aug. 27, 24- 2024/2025

 :-- Often develops in a characteristic pattern in patients with malignancy.

(Patients with malignancy may develop a characteristic migratory thrombophlebitis. This is

particularly associated with mucinous adenocarcinoma, but is also seen with acute leukemia.)




What does thrombomodulin do?


 :-- Thrombomodulin binds thrombin and prevents it from stimulating platelet

aggregation.




A 15-year-old boy has an anemia with spherocytes in his blood. Further work-up would be

expected to show


 :-- bone marrow with erythroid hyperplasia




Which of the following coagulation tests can be used for laboratory assessment of the listed

anticoagulant medication?

- Bleeding time: warfarin.

- Thrombin time: fibrinolytics.

- Activated partial thromboplastin time: warfarin.

- Platelet aggregation studies: fibrinolytics.

- Prothrombin time: heparin


 :-- Thrombin time: fibrinolytics.

(Measures the thrombin-induced conversion of fibrinogen to fibrin. Can be used to monitor

fibrinolytic therapy--satisfactory fibrinolytic state achieved when TT is two times normal.)



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, 3
Elscores: Aug. 27, 24- 2024/2025



Which of the following statements concerning ABH blood group antigens is correct?

- They are inherited as sex-linked recessive traits.

- They do not require prior blood exposure for antibody formation.

- They cause mild transfusion reactions.

- They are the only antigens which are tested in a routine type and cross match.

- They are not expressed in patients with Hageman disease.


 :-- They do not require prior blood exposure for antibody formation.

(Individuals who lack the A or B antigen on the surface of their erythrocytes possess strong IgM

antibodies to these antigens.)




Which of the following regarding heparin administration is correct?

- Absorption with intramuscular injection is similar to that of IV administration.

- Incomplete absorption with PO intake.

- IV administration produces immediate onset of action.

- Subcutaneous injection has steady absorption rate.

- IV bolus with sufficient dose can dissolve clots.


 :-- IV administration produces immediate onset of action.




In patients with von Willebrand`s disease, treatment for bleeding is most efficiently

accomplished by the administration of



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