Term 1 of 150
Why is normal thyroid function important in first trimester of pregnancy? How much does
requirement unusually increase in pregnant women taking thyroid supplements?
o Fetus is unable to produce its own hormones, without can result in permanent
neuropsychologic deficits
o Usually increases as much as 50%
o Surgical removal, destruction of the thyroid tissue, suppression of the thyroid hormone
synthesis and/or beta blockers
o Non-radioactive iodine can be used to distract the thyroid tissue
o Postmenopausal hormone therapy
o Dysfunctional uterine bleeding
o Amenorrhea
o Infertility
o Prematurity prevention
o Endometrial carcinoma and hyperplasia
Exercise increases cellular responsiveness to insulin and increases glucose tolerance o 150
minute per week of moderate intensity exercise is recommended
,Term 2 of 150
What are adverse effects of Testosterone?
o Preparations
Oral androgens: Fluoxymesterone and methyltestosterone
Intramuscular testosterone esters
Transdermal testosterone patches
Transdermal testosterone gels
Transdermal testosterone under arms
Implantable subcutaneous testosterone pellets
Testosterone buccal tablets
o Topical Applications
Pick the location for application
Avoid skin-to-skin contact transfer
Wash hands with soap and water after every application
Cover application site with clothing once gel is dry
Women and children: Avoid contact
Swimming and showering—5 to 6 hours after application
o Virilization in women, girls, and boys
o Premature epiphyseal closure
o Hepatotoxicity
o Effects on cholesterol levels
o Use in pregnancy
o Prostate cancer
o Edema
o Abuse potential (athletic performance)
o Hypertension, suppression of release of LH and FSH, testicular shrinkage, sterility,
gynecomastia, acne, reduction in HDL, increase in LDL
o Hepatotoxicity with 17-alpha-alkylated compounds
o Renal damage
o Psychologic effects
Mentally healthy: Minimal impact
Psychologically unbalanced: Could intensify aggression
o Influence the physiologic processes related to reproduction
o Affects the ductal growth in the breasts, the thickening and cornification of the vaginal
epithelium, the proliferation of the uterine epithelium, and the copious secretion of
thickened mucus form the endocervical glands
,Term 3 of 150
o What are the 3 delivery systems for inhaled treatments?
Erosive esophagitis, GERD, duodenal ulcers associated with H. Pylori infection,
prophylaxis of NSAID induced ulcers
Administer 2-3 times daily to provide glycemic control between meals and during the
night
, Term 6 of 150
Liotrix—a mixture of synthetic T4 plus synthetic T3 in a 4:1 fixed ratio
o Because levothyroxine alone produces the same ratio of T4 to T3, Liotrix offers no
advantage over levothyroxine for most indications
7%or below o Those with severe hypoglycemia risk, limited life expectancy ,advanced
microvascular or
macrovascular complications—not below 7
o Surgical removal, destruction of the thyroid tissue, suppression of the thyroid hormone
synthesis and/or beta blockers
o Non-radioactive iodine can be used to distract the thyroid tissue
Cimetidine—intensifies the response
Beta blockers—diminish the benefits by suppressing the insulin release
Term 7 of 150
o How do Carbonic anhydrase inhibitors (CAIs) work?
Lowers intraocular pressure by reducing aqueous humor production and
possibly by increasing outflow
Two approved: Apraclonidine and brimonidine
Reduces intraocular pressure by decreasing production of aqueous humor
Treatment of gerd and hypersecretory states
Inhibits the breakdown of acetylcholine and promotes accumulation of
acetylcholine at the muscarinic receptors
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