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PHM 350 Exam #4 Questions With Complete Solutions
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PHM 350 Exam #4 Questions With Complete Solutions
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PHM 350 Exam #4 Questions With Complete Solutions1st Generation Cephalosporins Correct Answers Cefazolin,
Cephalexin
- G+ and minimal G- activity
- very sensitve to penicillinase
- used when allergy to penicillin or prophylactic prior to surgery
2nd Generation Cephalosporin Correct Answers Cefoxitin
- increased effect in G-
- increased entry to CNS
- increased resistance to penicillinase
- used when allergy to penicillin or prophylactic prior to surgery
30S Inhibitor Drugs Correct Answers Tetracyclines (MDDT),
Aminoglycosides (SKNGT), Linezoid
30S Inhibitor: Aminoglycosides Correct Answers
Streptomycin, Kanamycin, Neomycin, Gentamycin, Tobramycin
30S Inhibitor: Linezoid [Mechanism of Action, Spectrum of
Action, Restrictions] Correct Answers Mechanism of Action
- bind and inhibit 30S
- bactericidal
- developed in response to increased resistance of G+ to
antibiotics like penicillin, vancomycin, cephalosporins
Spectrum of Action
- G+
Restrictions
,- undocumented, new drug
30S Inhibitors: Tetracyclines Correct Answers Minocycline,
Doxycycline, Demeclocycline, Tetracycline
3rd Generation Cephalosporin Correct Answers Cefotaxamine
- increase G+ and G- effectiveness
- increased resistance to penicillinase
- increased entry to CNS
- used for salmonella, meningitis, some nosocomial infections
4th Generation Cephalosporin Correct Answers Cefepime
- increased resistance to penicillinase
- increased spectrum of action
- increased entry to CNS
- used for salmonella, meningitis, some nosocomial infections
5-fluorouracil [Mechanism of Action] Correct Answers -
Antimetabolite
- Substitute for U (precursor of T)
- Produces abnormal DNA
- Failure of cell replication
- Failure of protein production = cell death
50S Inhibitors Correct Answers Erythromycin, Clindamycin
5th Generation Cephalosporins Correct Answers Ceftaroline,
Ceftobiprole
- increased absorption in GI
- increased resistance to penicillinase
- increased entry to CNS
, - Used to treat MRSA infections
6-mercaptopurine, Thioguanine [Mechanism of Action] Correct
Answers - Antimetabolites
- Substitute A and G in DNA
- Produces abnormal DNA
- Failure of cell replication
- Failure of protein production = cell death
Acetaminophen (Mechanism of Action and Uses) Correct
Answers Mechanism of Action
- block COX1 and COX2, prevent AA binding to enzyme
Uses
- Analgesic
- Antipyretic
- Substitute for hypersensitivity to aspirin
Alkylating Agent: Cisplatin [Mechanism of Action] Correct
Answers - Categorized under alkylating agents, but it doesn't
alkylate DNA
- Binds and cross links DNA
- inhibits DNA synthesis, protein synthesis, and cell replication
- Dose-limiting Side effect: Renal toxicity (can be prevented by
proper hydration]
Alkylating Agents Correct Answers Lomustine,
Mechlorethamine, Cyclophosphamide, Chlorambucil,
Carmustine (Nitrogen Mustards)
Cisplatin, Mitomycin
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