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Walden 6630 Psychopharmacology Midterm Study Guide With complete solution 2024/25
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Walden 6630 Psychopharmacology Midterm Study Guide With complete solution 2024/25
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Walden 6630 PsychopharmacologyMidterm Study Guide With complete
solution 2024/25
Serotonin regulates - Mood, emotion, feeding, and reproductive behavior
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This class of antidepressants binds to presynaptic SERT and inhibits them from reuptake
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of serotonin to increase levels in the synaptic cleft to bind with postsysnaptic 5HT2
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receptors - SSRIs
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II First line therapy for MDD due to milder side effect profiles - SSRIs
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Six Common SSRIs - citalopram, escitalopram, fluoxetine, fluvoxamine, sertraline,
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paroxetine
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II Onset of therapeutic benefit from SSRIs - 4-6 weeks
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In addition to MDD, SSRIs also treat - Chronic Anxiety, PTSD, OCD, and eating
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disorders (bulimia)
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Five Common side effects of SSRIs include - Anxiety, insomnia, GI distress, sexual
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dysfunction (ED), SIADH
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Severe side effect of SSRIs in children/adolescents under age 25 years old - suicidal
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ideation
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Life threatening adverse effect of SSRIs, especially when used in combination with other
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serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) - Serotonin Syndrome
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Excess accumulation of serotonin resulting in overstimulation of the nervous system -
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Serotonin Syndrome
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Seven symptoms of Serotonin Syndrome - Flushing, hyperthermia, agitation, muscle
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rigidity, seizure, coma, HYPERreflexia
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II The treatment for serotonin syndrome - Cyproheptadine (5-HT2 receptor antagonist)
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Cyproheptadine treats serotonin syndrome by - blocking 5-HT2 receptors (serotonin
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antagonist)
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When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal include -
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Irritability, headaches, and insomnia
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, Medicine specific side effect of citalopram - Prolonged QT interval (normal=0.4.-0.44
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seconds)
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This SSRI is pregnancy category D due to associations with congenital heart defects -
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Paroxetine
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II All SSRIs but paroxetine (D) are pregnancy category - C
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Three SSRIs that are inhibitors of Cytochrome P450 enzymes - fluoxetine, fluvoxamine,
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and paroxetine
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Five common SNRIs include - duloxetine, venlafaxine, desvenlafaxine, milnacipran,
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levomilnacipran
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This antidepressant class of medications works by binding to presynaptic SERT and NET
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to inhibit them from reuptake of serotonin and norepinephrine to increase their levels in
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the synaptic cleft - SNRIs
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II In addition to MDD SNRIs treat - Anxiety and neuropathic pain (peripheral neuropathy)
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II Medication specific indications of duloxetine: - urinary incontinence and Fibromyalgia
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Medication specific indications of venlafaxine: - social anxiety, panic disorders, PTSD,
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OCD, postmenopausal hot flashes
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Six common side effects of SNRIs include: - Insomnia, nausea, sexual dysfunction,
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hypertension, sweating, headaches
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Severe side effect of SNRIs in children/adolescents under age 25 years old: - suicidal
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ideation
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Life threatening adverse effect of SNRIs, especially when used in combination with other
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serotonergic drugs: - Serotonin Syndrome
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II This SNRI is an inhibitor of Cytochrome P450 enzymes: - venlafaxine
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II This SNRI is hepatotoxic: - duloxetine
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II MAOIs increase the levels of: - Serotonin, Norepinephrine, and Dopamine
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II Norepinephrine regulates: - alertness and focus II II II II II II II
II Dopamine regulates: - cognitive function, motivation, and awakeness
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In the synaptic cleft, Monoamine Oxidase A breaks down: - Serotonin, Norepinephrine,
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and Dopamine
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