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Kuby Immunology Exam 1 (Ch. 1-5)
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Kuby Immunology Exam 1 (Ch. 1-5)
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Immunology Kuby Chapter 5 InnateImmunity
1. Which of the following is NOT entirely a response of the innate immune system?
A. Phagocytosis by macrophages
B. Protection from infection by the skin
C. Low pH in the stomach
D. Antibody mediated complement activation
E. Microbial cell lysis by defensin - ANS-Answer: D
Section: Introduction
Difficulty: 2
Hint: What makes antibodies?
10. Match the following toll-like receptors with their ligands.
TLR Ligands
TLR3 Flagellin
TLR4 Zymosan
TLR5 dsRNA
TLR6 CpG unmethylated dinucleotides
TLR9 LPS
A. TLR3/LPS; TLR4/CpG unmethylated dinucleotides; TLR5/dsRNA; TLR6/Zymosan;
TLR9/Flagellin
B. TLR3/dsRNA; TLR4/LPS; TLR5/Flagellin; TLR6/Zymosan; TLR9/CpG unmethylated
dinucleotides
C. TLR3/dsRNA; TLR4/LPS; TLR5/CpG unmethylated dinucleotides; TLR6/Flagellin;
TLR9/Zymosan
D. TLR3/CpG unmethylated dinucleotides; TLR4/Zymosan; TLR5/Flagellin; TLR6/LPS;
TLR9/dsRNA
E. TLR3/Zymosan; TLR4/LPS; TLR5/Flagellin; TLR6/dsRNA; TLR9/CpG unmethylated
dinucleotides - ANS-Answer: B
Section: Induced Cellular Innate Responses
Difficulty: 1
Hint: Review Table 5-4.
11. Which of the following is NOT usually induced in response to TLR signaling?
, A. TNF-α
B. IL-1
C. iNOS
D. IL-6
E. IL-4 - ANS-Answer: E
Section: Induced Cellular Innate Responses
Difficult: 2
Hint: TLR signaling often leads to inflammation.
12. Where would you MOST likely find a TLR that recognizes RNA?
A. On the cell surface
B. In the endosome/lysosome
C. In the nucleus
D. In the mitochondria
E. In the endoplasmic reticulum - ANS-Answer: B
Section: Induced Cellular Innate Responses
Difficulty: 2
Hint: RNA receptors are often found where viruses uncoat and disassemble.
13. Which of the following adaptor proteins activate the NF-κB pathway?
A. MyD88
B. IKKα
C. Calmodulin
D. IL-2 receptor
E. SOS - ANS-Answer: A
Section: Induced Cellular Innate Responses
Difficulty: 1
Hint: The key to this question is the word "adaptor."
14. Which cytokine is known for its anti-viral properties?
A. IL-2
B. IL-4
C. IFN-α
D. TNF-α
E. IL-1 - ANS-Answer: C
Section: Induced Cellular Innate Responses
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