ABGC Boards Prenatal Study Set
T21 Risk by Maternal Age - Answer-Age-------------------------------Risk
30 --------------------------------1/952 (.1%)
35 --------------------------------1/385 (.3%)
37 --------------------------------1/227 (.4%)
40 --------------------------------1/106 (.9%)
43 --------------------------------1/50 (3.1%)
Risk of Any Chrom Abnl by Maternal Age - Answer-Age--------------------------------Risk
30---------------------------------1/384 (0.3%)
35---------------------------------1/202 (0.5%)
37---------------------------------1/129 (0.8%)
40---------------------------------1/65 (1.6%)
43---------------------------------1/32 (3.1%)
Maternal Serum Quad Screen - Answer-Measurement of biochemical analytes in
maternal serum to provide adjusted risk for certain conditions.
Performed during second trimester typically 14-21 weeks
SLO vs XL ichthyosis,
SLO has pre and postnatal growth restrictions - Answer-Differentials for extremely
low uE3 on QUAD screen and how can you differentiate
Non-disjunction in Meiosis I - Answer-What is the most common cause of aneuploidy
Factors to take into account for Quad Screen - Answer-Gestational Age: As this
changes so does expected values of each analyte
Weight: as maternal weight increases so does blood volume. Dilutes analytes
Race: Different ethnic backgrounds can affected expected levels
- i.e. African American ancestry tend to have higher AFP levels
, -Diabetic status: insulin dependent diabetics tend to have lower AFP
Effects of inaccurate dating for Quad Screen - Answer--Overestimate (believe
pregnancy is further along) can lead to false positive for Down syndrome.
(Overestimate brings you down)
- Underestimate (reported to be earlier than it is) leads to false positive for NTD.
London (The under is the tubes)
- Generally use first trimester ultrasound for dating rather than LMP
IgM (Most recent)
IgG (It is gone) - Answer-You see IgM but not IgG is this more concerning for recent
infections due to maternal infection.
Memory device
Estriol and hCG low but AFP high early
All low: Late - Answer-Patterns for recent and older fetal demise
Trends of Analytes in Second Trimester - Answer-Analyte Trend
hCG Decreases as GA increases
Inhibin Remains Stable
uE3 Increases with GA
AFP increases with GA
Positive Quad screen pattern Increased risk for Down Syndrome - Answer-HI
(Increased) LO (Decreased)
Pattern of Quad screen with abnormal placental functioning - Answer-AFP: HI
hCG: High
uE3: Low
Inhibin: High
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