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WGU 785 Final Exam Latest 2021 With Complete Solution
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WGU 785 Final Exam Latest 2021 With Complete Solution1. Hemophilia Pedigree - Father has hemophilia, mother does not. What is
the outcome for their kids?: Answer- His daughters would be carriers.
This is x-link recessive.
2. Autosomal:
Dominant:: Answer- Autosomal: males and females
equally affected. Dominant: non-carrier parents
3. polymerase chain reaction (PCR): Answer- The process of copying DNA
in the lab. Uses Template DNA, Nucleotides (dNTPS), DNA Polymerase,
and DNA primers.
4. 3 Steps of PCR: Answer- 1. Denaturation: DNA is heated to 95C to
separate it.
2.Annealing: reaction is cooled to 50C; primers stick to the DNA you
want to copy and add DNA polymerase.
3. Elongation: reaction heated to 70C and DNA polymerase, adding
nucleotides building a new DNA strand.
5. Base Excision Repair (BER): Answer- How you repair a mutation. BER
is used to repair damage to a base caused by harmful molecules. You
remove the base that is damaged and replace it. *BER removes a
single nucleotide*
DNA glycolsylase - sees damaged DNA and removes it.
DNA polymerase-puts the right one back in while DNA ligase seals it.
,6. Mismatch repair (MMR) occurs during:: Answer- replication. DNA
polymerase proof- reads but sometimes a mismatch pair gets through.
MMR removes a large section of the nucleotides from the new DNA
and DNA polymerase tries again. (Ex: C-T instead of C-A)
7. Mismatch Repair corrects what kind of DNA damage?: When a base is
mis- matched due to errors in replication. Such as G-T instead of G-C.
DNA polymerase comes by and fixes it.
8. What happens when DNA polymerase binds to DNA to make RNA?:
TRAN- SCRIPTION! DNA polymerase takes the individual nucleotides
and matches them to the parental sequences to ensure a correct pair.
It must bind with RNA primer to work.
9. What is needed for DNA replication?: DNA polymerase
10.Nonsense Mutation: Change in 1 nucleotide produces a STOP codon
Stop= nonsense because it is no more.
11.Silent Mutation: Change in 1 nucleotide but codes for the same
amino acid. Silent= the change doesn't change the name of the
protein
12.Missense Mutation: Change in 1 nucleotide leads to a code for a
different amino acid. Missense = mistake was made.
, 13.What happends during RNA splicing?: During RNA splicing introns
are cut out, the remaining exons are joined together.
14. 5'ATG AGT CTC TCT 3'
Find the DNA template strand.: 3'TAC TCA GAG AGA 5'
The DNA template strand is complimentary. So start with the opposite
number, then go L-R with the complimentary letter.
15. 5'ATG AGT CTC TCT 3'
What is the corresonding mRNA sequence?: 5'AUG AGU CUC UCU 3'
This sequence is the same as the coding strand except T changes to U
because it is RNA. RNA doesn't have T.
16.How would a mutation from CTC to ATC affect the protein sequence?
(CTC/ATC - coding strand, AUC - mRNA strand): This will make a
missense mutation because it changes the name of the protein. (look
at the chart provided.) missense = mistake
17.DNA replication process: DNA ->Transcription -> RNA ->
Translation -> Polypeptide
18.Describe how you would find what ionized Alanine looks like.: This is
an amino acid. Look for the "R" group. Alanine is a hydrophobic amino
acid that has CH3. It is a weak interaction. An ionized acid will have a
+ or - charge.
19. Describe what causes the misfolding of protein in Alzheimer's Disease.-
: Protein misfolding is caused by intracellular tangles and
extracellular plaques (senile plaques) caused by abnormal protein
aggregation.
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